Studies of π-diastereofacial selectivity: Spiro 2-tetrahydrofuran and 2-tetrahydrothiophene ketones

  • Dimitroff M
  • Fallis A
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The facial influence and synthetic utility of oxygen, sulfur and carbon atoms adjacent to the ketone in the series of α-spiro ketones 2, 3, and 4 upon nucleophilic addition has been examined. Addition to the carbonyl group displayed a preference for attack anti to the heteroatom in competition with carbon in synthetically useful ratios. Hydride reduction of 2 with chelating reagenst (NaBH4, LiAlH4etc.) reversed this facial preference.

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  • Martin Dimitroff

  • Alex G. Fallis

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