Studies in bile salt solutions. Deoxycholate stimulation of human milk lipase

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Abstract

Stimulation of human milk lipase by deoxycholate and its taurine and glycine conjugates was demonstrated by measuring the esterolysis reaction of 4-nitrophenylacetate. The steroidal surfactants did not bind strongly to the polar substrate but they did bind effectively to a hydrophobic site on the enzyme and these bile salt-enzyme complexes were effective catalysts. These results are compared with those for stimulation of the enzyme by cholate surfactants and it has been demonstrated that the absence of a 7α-OH substituent on the steriod nucleus does not prevent stimulation of either the esterolytic or lipolytic activity of the enzyme. © 1984.

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O’Connor, C. J., & Wallace, R. G. (1984). Studies in bile salt solutions. Deoxycholate stimulation of human milk lipase. FEBS Letters, 170(2), 375–377. https://doi.org/10.1016/0014-5793(84)81347-2

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