Studies in bile salt solutions. Deoxycholate stimulation of human milk lipase

  • O'Connor C
  • Wallace R
  • 1


    Mendeley users who have this article in their library.
  • 7


    Citations of this article.


Stimulation of human milk lipase by deoxycholate and its taurine and glycine conjugates was demonstrated by measuring the esterolysis reaction of 4-nitrophenylacetate. The steroidal surfactants did not bind strongly to the polar substrate but they did bind effectively to a hydrophobic site on the enzyme and these bile salt-enzyme complexes were effective catalysts. These results are compared with those for stimulation of the enzyme by cholate surfactants and it has been demonstrated that the absence of a 7α-OH substituent on the steriod nucleus does not prevent stimulation of either the esterolytic or lipolytic activity of the enzyme. © 1984.

Author-supplied keywords

  • Bile salt-stimulated lipase
  • Esterase activity
  • Human milk lipase

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Charmian J. O'Connor

  • Robert G. Wallace

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free