Study of the restitution of action potential duration using the artificial neural network

  • Han X
  • Chen Y
  • Gao W
 et al. 
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It is widely accepted that the APD (action potential duration) restitution plays a key role in the initializing and maintaining of the reentry arrhythmias. The Luo-Rudy II models paced with different protocols showed that the current APD had a complex relation with the previous APDs and diastole intervals (DIs). This relation could not be accurately described by a single exponential function. We used an artificial neural network to formularize this relation. The results suggested that back-propagation (BP) network could predict the current APD from the information of the first three previous beats. This would help provide a target for potential anti-arrhythmic therapies.

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  • X Han

  • Y Chen

  • W Gao

  • J Xue

  • Z Fang

  • C Yang

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