It is widely accepted that the APD (action potential duration) restitution plays a key role in the initializing and maintaining of the reentry arrhythmias. The Luo-Rudy II models paced with different protocols showed that the current APD had a complex relation with the previous APDs and diastole intervals (DIs). This relation could not be accurately described by a single exponential function. We used an artificial neural network to formularize this relation. The results suggested that back-propagation (BP) network could predict the current APD from the information of the first three previous beats. This would help provide a target for potential anti-arrhythmic therapies. © 2006 Elsevier Inc. All rights reserved.
Han, X., Chen, Y., Gao, W., Xue, J., Han, X., Fang, Z., … Wu, X. (2007). Study of the restitution of action potential duration using the artificial neural network. Mathematical Biosciences, 207(1), 78–88. https://doi.org/10.1016/j.mbs.2006.09.019