The effects of posttrial injections of amphetamine, pentylenetetrazol and strychnine on the performance of trained rats in a Lashley III maze and in a shuttle box were studied. The first two drugs, at doses of 2.0 and 20.0 mg/kg, respectively, were able to impair the performance of the animals after a few posttrial injections. Strychnine at doses from 0.2 to 1.30 mg/kg was ineffective. The disruption of performance produced by the two drugs was tentatively explained on the basis of an approach-avoidance conflict set up by some aversive properties of amphetamine and pentylenetetrazol. The mode of action of the three drugs was discussed to explain the lack of effect of strychnine. © 1972 Academic Press, Inc. All rights reserved.
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