A suggested aversive effect in rats of posttrial administration of central nervous system stimulants

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Abstract

The effects of posttrial injections of amphetamine, pentylenetetrazol and strychnine on the performance of trained rats in a Lashley III maze and in a shuttle box were studied. The first two drugs, at doses of 2.0 and 20.0 mg/kg, respectively, were able to impair the performance of the animals after a few posttrial injections. Strychnine at doses from 0.2 to 1.30 mg/kg was ineffective. The disruption of performance produced by the two drugs was tentatively explained on the basis of an approach-avoidance conflict set up by some aversive properties of amphetamine and pentylenetetrazol. The mode of action of the three drugs was discussed to explain the lack of effect of strychnine. © 1972 Academic Press, Inc. All rights reserved.

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Carlini, E. L. de A., de Lorenzo, R. M. T., & de Almeida, E. T. (1972). A suggested aversive effect in rats of posttrial administration of central nervous system stimulants. Behavioral Biology, 7(3), 391–400. https://doi.org/10.1016/S0091-6773(72)80111-1

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