Survey of plant inhibitors of polymorphonuclear leukocyte elastase, pancreatic elastase, cathepsin G, cathepsin B, hageman factor fragments, and other serine proteinases

  • Hojima Y
  • Pisano J
  • Cochrane C
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Abstract

Various flower bulbs and vegetable and legume seeds were tested for inhibitors of polymophonuclear leukocyte elastase, pancreatic elastase, cathepsin G, cathepsin B, trypsin, α-chymotrypsin, Hageman factor fragments, plasma kallikrein, and plasmin. Calla bulbs contained a 33,000 dalton polymorphonuclear leukocyte elastase inhibitor and a 4,000 dalton cathepsin G inhibitor. Seeds of some members in the Cruciferae family, such as radish and broccoli, were found to contain one or more 2,500-4,000 dalton inhibitors which inhibited pathepsin G, trypsin, Hageman factor fragments, and plasmin, but not plasma kallikrein. These seeds also contained a 1,000 dalton cathepsin B inhibitor. The above inhibitors were probably polypeptides which inhibited proteinases by making an enzyme inhibitor complex, with the exception of the cathepsin B inhibitor. These newly found inhibitors with their characteristic profiles of inhiibition should be useful in biochemical and pathophysiological studies on granulocyte proteinases and enzymes of the coagulation and fibrinolytic pathways. © 1983.

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Authors

  • Yoshio Hojima

  • John J. Pisano

  • Charles G. Cochrane

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