Synaptic inhibition and cell communication; impairment of cell-to-cell coupling produced by γ-aminobutyric acid (GABA) in the somatic musculature of Ascaris lumbricoides

  • De Mello W
  • Maldonado H
  • 3

    Readers

    Mendeley users who have this article in their library.
  • 5

    Citations

    Citations of this article.

Abstract

The influence of γ-aminobutyric acid (GABA) (10-5M) on the electrical coupling of giant somatic muscle cells of Ascaris lumbricoides was investigated. GABA enhanced the resting potential of the cells and abolished the spike activity. The coupling coefficient (V2/V1) was reduced by 58.8% while the input resistance (Rin) was decreased by 38.8%. The decline in Rinwas not related to unlinearity of the current-voltage relation. As the time constant of cell membrane was reduced by 28.4% by the addition of GABA the effect of the neurotransmitter on cell-to-cell coupling seems to be mainly related to a decrease in resistance of the nonfunctional membrane due to an increase in chloride conductance. © 1985.

Author-supplied keywords

  • Ascaris
  • GABA
  • electrical coupling

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • W. C. De Mello

  • H. Maldonado

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free