The influence of γ-aminobutyric acid (GABA) (10-5M) on the electrical coupling of giant somatic muscle cells of Ascaris lumbricoides was investigated. GABA enhanced the resting potential of the cells and abolished the spike activity. The coupling coefficient (V2/V1) was reduced by 58.8% while the input resistance (Rin) was decreased by 38.8%. The decline in Rinwas not related to unlinearity of the current-voltage relation. As the time constant of cell membrane was reduced by 28.4% by the addition of GABA the effect of the neurotransmitter on cell-to-cell coupling seems to be mainly related to a decrease in resistance of the nonfunctional membrane due to an increase in chloride conductance. © 1985.
De Mello, W. C., & Maldonado, H. (1985). Synaptic inhibition and cell communication; impairment of cell-to-cell coupling produced by γ-aminobutyric acid (GABA) in the somatic musculature of Ascaris lumbricoides. Cell Biology International Reports, 9(9), 803–813. https://doi.org/10.1016/0309-1651(85)90099-2