A Ziegler-Natta catalyst system (TiCl4-MgCl2/magnesium chloride-methanol adduct) was efficiently found to catalyze the three component Biginelli reaction of an aldehyde, β-keto ester, and urea or thiourea under solvent free conditions to afford the corresponding 3,4-dihydropyrimidin-2-(1H)-ones in excellent yields. The enhanced surface areas of TiCl4-MgCl2-methanol adduct plays significant role in providing an efficient synthesis of Biginelli compounds. © 2007 Elsevier B.V. All rights reserved.
Kumar, A., & Maurya, R. A. (2007). Synthesis of 3,4-dihydropyrimidin-2(1H)-ones using Ziegler-Natta catalyst system under solvent free conditions. Journal of Molecular Catalysis A: Chemical, 272(1–2), 53–56. https://doi.org/10.1016/j.molcata.2007.03.026