3-Alkylidene-piperidin-4-ones with diverse C-5 substitution patterns are synthesized via a one-pot cascade transylidation-olefination sequence. Tributylphosphorus ylides show distinct higher reactivity as compared to triphenyl analogs. t-Butanol is the solvent of choice for transylidation, while the Wittig olefination of aliphatic aldehydes requires MeCN as the solvent. © 2009 Elsevier Ltd. All rights reserved.
Wang, B. (2009). Synthesis of 3-alkylidene-piperidin-4-ones via one-pot cascade transylidation-olefination. Tetrahedron Letters, 50(21), 2487–2489. https://doi.org/10.1016/j.tetlet.2009.03.023