Synthesis and biological evaluation of novel steroid-linked nitrogen mustards

  • Zhang H
  • Xue J
  • Zhao X
 et al. 
  • 4

    Readers

    Mendeley users who have this article in their library.
  • 10

    Citations

    Citations of this article.

Abstract

Two novel steroid-linked nitrogen mustard conjugates 1a and 1b were synthesized by using estrogenic acid 4 coupled with aniline mustard 8 and phenol mustard 13 in an esterification or amidation procedure. Preliminary cytotoxic screening on cancer cell lines in vitro showed that, the steroid-ester linked nitrogen mustard conjugate 1a exhibited obvious increasing of activities. © 2009 Ying Li.

Author-supplied keywords

  • Biological activity
  • Nitrogen mustards
  • Steroid
  • Synthesis

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Degang LiuIndiana University School of Medicine

    Follow
  • Hua Bing Zhang

  • Ji Jun Xue

  • Xiao Long Zhao

  • Ying Li

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free