Synthesis and biological evaluation of novel steroid-linked nitrogen mustards

  • Zhang H
  • Xue J
  • Zhao X
 et al. 
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Two novel steroid-linked nitrogen mustard conjugates 1a and 1b were synthesized by using estrogenic acid 4 coupled with aniline mustard 8 and phenol mustard 13 in an esterification or amidation procedure. Preliminary cytotoxic screening on cancer cell lines in vitro showed that, the steroid-ester linked nitrogen mustard conjugate 1a exhibited obvious increasing of activities. © 2009 Ying Li.

Author-supplied keywords

  • Biological activity
  • Nitrogen mustards
  • Steroid
  • Synthesis

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  • Degang LiuIndiana University School of Medicine

  • Hua Bing Zhang

  • Ji Jun Xue

  • Xiao Long Zhao

  • Ying Li

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