Synthesis and biological evaluation of novel steroid-linked nitrogen mustards

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Abstract

Two novel steroid-linked nitrogen mustard conjugates 1a and 1b were synthesized by using estrogenic acid 4 coupled with aniline mustard 8 and phenol mustard 13 in an esterification or amidation procedure. Preliminary cytotoxic screening on cancer cell lines in vitro showed that, the steroid-ester linked nitrogen mustard conjugate 1a exhibited obvious increasing of activities. © 2009 Ying Li.

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Zhang, H. B., Xue, J. J., Zhao, X. L., Liu, D. G., & Li, Y. (2009). Synthesis and biological evaluation of novel steroid-linked nitrogen mustards. Chinese Chemical Letters, 20(6), 680–683. https://doi.org/10.1016/j.cclet.2009.01.023

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