Synthesis and characterization of [186Re]rhenium(V)dimercaptosuccinic acid: A possible tumour radiotherapy agent

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Abstract

[186Re]Re(V)DMSA, a β-emitting analogue of the tumour imaging radiopharmaceutical pentavalent [99mTc]Tc(V)DMSA of possible value in tumour therapy, is readily prepared by stannous reduction of [186Re]ReO4-in the presence of dimercaptosuccinic acid at 100°C using a commercial DMSA kit as used for renal imaging with99mTc, and purified using a disposable sample preparation column. The complex has been identified as [ReO(DMSA)2]-by NMR, optical and i.r. spectroscopy and elemental analysis. © 1991.

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Bisunadan, M. M., Blower, P. J., Clarke, S. E. M., Singh, J., & Went, M. J. (1991). Synthesis and characterization of [186Re]rhenium(V)dimercaptosuccinic acid: A possible tumour radiotherapy agent. International Journal of Radiation Applications and Instrumentation. Part, 42(2), 167–171. https://doi.org/10.1016/0883-2889(91)90068-C

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