Synthesis and characterization of [186Re]rhenium(V)dimercaptosuccinic acid: A possible tumour radiotherapy agent

  • Bisunadan M
  • Blower P
  • Clarke S
 et al. 
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[186Re]Re(V)DMSA, a β-emitting analogue of the tumour imaging radiopharmaceutical pentavalent [99mTc]Tc(V)DMSA of possible value in tumour therapy, is readily prepared by stannous reduction of [186Re]ReO4-in the presence of dimercaptosuccinic acid at 100°C using a commercial DMSA kit as used for renal imaging with99mTc, and purified using a disposable sample preparation column. The complex has been identified as [ReO(DMSA)2]-by NMR, optical and i.r. spectroscopy and elemental analysis. © 1991.

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  • M. M. Bisunadan

  • P. J. Blower

  • S. E.M. Clarke

  • J. Singh

  • M. J. Went

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