Synthesis of chloroquinocin, a pyranonaphthoquinone antibiotic against Gram-positive bacteria

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Abstract

Chloroquinocin 1 is an antimicrobial agent against Gram-positive bacteria, including MRSA (methicillin-resistant Staphylococcus aureus). A successful synthesis of 1 was attained through a unique chlorination of the corresponding naphthoquinone derivative 12 as a key step. © 2007 Elsevier Ltd. All rights reserved.

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Shimbashi, A., & Nishiyama, S. (2007). Synthesis of chloroquinocin, a pyranonaphthoquinone antibiotic against Gram-positive bacteria. Tetrahedron Letters, 48(9), 1545–1548. https://doi.org/10.1016/j.tetlet.2007.01.020

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