Synthesis of chloroquinocin, a pyranonaphthoquinone antibiotic against Gram-positive bacteria

  • Shimbashi A
  • Nishiyama S
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Abstract

Chloroquinocin 1 is an antimicrobial agent against Gram-positive bacteria, including MRSA (methicillin-resistant Staphylococcus aureus). A successful synthesis of 1 was attained through a unique chlorination of the corresponding naphthoquinone derivative 12 as a key step. © 2007 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • Antibiotic
  • Chlorination
  • Chloroquinocin
  • Gram-positive bacteria
  • Methicillin-resistant Staphylococcus aureus
  • Pyranonaphthoquinone

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Authors

  • Akiko Shimbashi

  • Shigeru Nishiyama

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