Synthesis and conformational analysis of 2,6-dimethyl-1,5-diaza-cis-decalins

  • Kozlowski M
  • Xu Z
  • Santos A
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The stereoselective synthesis of 2,6-dimethyl-1,5-diaza-cis-decalins with the dimethyl groups syn or anti to the angular hydrogens has been accomplished starting from 1,5-diaza-cis-decalin. From an NMR study of the conformational properties of all three 2,6-dimethyl-1,5-diaza-cis-decalins, the components which affect the conformational equilibrium have been identified.

Author-supplied keywords

  • chiral diamine
  • conformational switch
  • diazadecalin

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  • Marisa C Kozlowski

  • Zhenrong Xu

  • A.Gil Santos

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