Synthesis of cordiaquinone J and K via B-alkyl Suzuki-Miyaura coupling as a key step and determination of the absolute configuration of natural products

Abstract

A versatile methodology for the synthesis of various terpenoids via B-alkyl Suzuki-Miyaura coupling as a key step is established. Synthesis of cordiaquinone J and K, new antifungal and larvicidal meroterpenoids, was achieved by using this methodology. The absolute configurations of cordiaquinone J and K were confirmed by the synthesis. © 2005 Elsevier Ltd. All rights reserved.