Synthesis of the cyclic nonapeptide of chlorofusin using a convergent [3+3+3]-fragment coupling strategy

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Abstract

A [3+3+3]-fragment coupling strategy was successfully applied in the synthesis of the nonacyclopeptide of chlorofusin, a potent natural antagonist against p53-MDM2 interactions. The accomplished convergent synthesis includes parallel syntheses of three tripeptides and their sequential assembly, and macrocyclization of the linear precursor to the required 27-membered nonacyclopeptide. © 2010 Elsevier Ltd. All rights reserved.

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Wang, Y. L., Qian, W. J., Wei, W. G., Zhang, Y., & Yao, Z. J. (2010). Synthesis of the cyclic nonapeptide of chlorofusin using a convergent [3+3+3]-fragment coupling strategy. Tetrahedron, 66(19), 3427–3432. https://doi.org/10.1016/j.tet.2010.03.032

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