Synthesis of an external beta-turn based on the GLDV motif of cell adhesion proteins

  • Davies D
  • Doyle P
  • Hill R
 et al. 
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Abstract

The (3S,6S,10S)-7/5 bicyclic lactam 8, designed as an external turn constraint, was synthesised by a new stereoselective route involving Eschenmoser condensation. The cyclic peptide 35 containing the integrin recognition motif GLDV added across the amino and carboxyl groups of the lactam external constraint 8 was prepared. Graphical Abstract. © 2004 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • Bicyclic lactam
  • Eschenmoser olefination
  • Integrin

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Authors

  • David E. Davies

  • Paul M. Doyle

  • Richard D. Hill

  • Douglas W. Young

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