Abstract
The (3S,6S,10S)-7/5 bicyclic lactam 8, designed as an external turn constraint, was synthesised by a new stereoselective route involving Eschenmoser condensation. The cyclic peptide 35 containing the integrin recognition motif GLDV added across the amino and carboxyl groups of the lactam external constraint 8 was prepared. Graphical Abstract. © 2004 Elsevier Ltd. All rights reserved.
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Davies, D. E., Doyle, P. M., Hill, R. D., & Young, D. W. (2005). Synthesis of an external beta-turn based on the GLDV motif of cell adhesion proteins. Tetrahedron, 61(1), 301–312. https://doi.org/10.1016/j.tet.2004.09.037
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