Synthesis of homoallylic oxygenated α-methylene-γ-butyrolactones: a model for preparing biologically active natural lactones

  • Sass D
  • Oliveira K
  • Constantino M
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Abstract

In this Letter we describe a 12% overall yield synthesis of a model for homoallylic oxygenated α-methylene-γ-butyrolactones with relative stereochemistry defined by selective hydrogenation with Rh/Al2O3. The synthesis was realized in 9 steps involving simple reactions. © 2008 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • Natural products
  • Synthesis
  • α-Methylene-γ-butyrolactones

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Authors

  • Daiane Cristina Sass

  • Kleber Thiago de Oliveira

  • Mauricio Gomes Constantino

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