Thiophosphoramidite as well as thiophosphoramidate chemistry has been used to prepare dithiophosphate analogues of oligonucleotides. The1H and13P resonances of the 3′-thymidine phosphorodithioate decamer d(CGCTpS-2TpS-2AAGCG) were assigned by two-dimensional NMR and the solution structure determined. © 1991.
Piotto, M. E., Granger, J. N., Cho, Y., Farschtschi, N., & Gorenstein, D. G. (1991). Synthesis, NMR and structure of oligonucleotide phosphorodithioates. Tetrahedron, 47(14–15), 2449–2461. https://doi.org/10.1016/S0040-4020(01)81780-4