Synthesis and pharmacological activities of 13-dehydro derivatives of primary prostaglandins

  • Tanami T
  • Kameo K
  • Ono N
 et al. 
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Abstract

13-Dehydro derivatives of prostaglandin E1, E2, E3, F(1α) and F(2α) were synthesized. Compared with natural prostaglandins, 13-dehydro analogues were found to exhibit more potent inhibitory activity against human platelet aggregation and relaxation of guinea-pig isolated trachea, while they showed less potent activity of contraction of guinea-pig isolated ileum.

Author-supplied keywords

  • Agonists
  • Prostaglandins

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