Synthesis and pharmacological activities of 13-dehydro derivatives of primary prostaglandins

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Abstract

13-Dehydro derivatives of prostaglandin E1, E2, E3, F(1α) and F(2α) were synthesized. Compared with natural prostaglandins, 13-dehydro analogues were found to exhibit more potent inhibitory activity against human platelet aggregation and relaxation of guinea-pig isolated trachea, while they showed less potent activity of contraction of guinea-pig isolated ileum.

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Tanami, T., Kameo, K., Ono, N., Nakagawa, T., Annou, S., Tsuboi, M., … Sato, F. (1998). Synthesis and pharmacological activities of 13-dehydro derivatives of primary prostaglandins. Bioorganic and Medicinal Chemistry Letters, 8(12), 1507–1510. https://doi.org/10.1016/S0960-894X(98)00247-9

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