Synthesis and properties of a pyrrole-imidazole polyamide having a ferrocene dicarboxylic amide linker

Abstract

A new minor groove binder having a redox-active ferrocene linker was synthesized and its DNA binding and redox activity were clarified. A new minor groove binder 1 having a redox active ferrocene dicarboxamide linker was synthesized. The affinity of the newly synthesized compound to the target DNA was confirmed by CD titration experiments. Moreover, the redox property of 1 was also demonstrated by cyclic voltammetry. These results suggest the potential of 1 as a new tool for electrochemical gene detection technology. © 2004 Elsevier Ltd. All rights reserved.