Synthesis of prospective disaccharide ligands for Escherichia coli O157 verotoxin

  • Bernlind C
  • Homans S
  • Field R
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The synthesis of new potential ligands for Escherichia coli 0157 verotoxin is reported, based on disaccharide fragments of the tetrasaccharide glycan portion of Gb4glycolipid. Intramolecular aglycone delivery was employed for the high-yielding and stereoselective production of the azidopropyl-tethered α-galactoside building block. © 2009 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • Disaccharide
  • Gb3
  • Gb4
  • Glycosylation
  • Intramolecular aglycone delivery (IAD)
  • Verotoxin

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  • Rob FieldJohn Innes Centre Department of Biological Chemistry

  • Christian Bernlind

  • Steven W. Homans

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