Synthesis of the pyrimidine analog of 4,5,6,7-tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)one (TIBO) potential for HIV-1 inhibition

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Abstract

Efficient synthesis of the pyrimidine TIBO analog 3, starting from 9-benzyl-6- chloropurine and testing of its ability to inhibit the replication of the HIV-1 virus in MT-4 cells are described. © 1991.

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Ho, C. Y., & Kukla, M. J. (1991). Synthesis of the pyrimidine analog of 4,5,6,7-tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)one (TIBO) potential for HIV-1 inhibition. Bioorganic and Medicinal Chemistry Letters, 1(10), 531–534. https://doi.org/10.1016/S0960-894X(01)80460-1

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