Synthesis of (S)-1-(4-hydroxyphenyl)alcohols by eugenol dehydrogenase from Pseudomonas fluorescens E118

  • Wieser M
  • Furukawa H
  • Morita H
 et al. 
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Abstract

(S)-1-(4-Hydroxyphenyl)ethanol and (S)-1-(4-hydroxyphenyl)propanol were synthesized with enantiomeric excesses of 96.6% and 95.2%, respectively, from the corresponding 4-alkylphenols by eugenol dehydrogenase from Pseudomonas fluorescens E118. The enantioselectivity of the enzyme was shown to be pH- dependent.

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Authors

  • Marco Wieser

  • Hirotaka Furukawa

  • Hiroshi Morita

  • Toyokazu Yoshida

  • Toru Nagasawa

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