Synthesis of SB 222618. A potential PDE IV inhibitor

  • Conde J
  • Mendelson W
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Abstract

PDE IV inhibitor SB 222618 was prepared by regioselective S(N)2' addition of 9 to bromoallene 6a followed by a stereoselective borane reduction of 4 to afford 2 which by a palladium mediated coupling with 3, delivered SB 222618 (1) in good yield. (C) 2000 Elsevier Science Ltd.

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Authors

  • Jose J. Conde

  • Wilford Mendelson

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