Synthesis of SB 222618. A potential PDE IV inhibitor

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Abstract

PDE IV inhibitor SB 222618 was prepared by regioselective S(N)2' addition of 9 to bromoallene 6a followed by a stereoselective borane reduction of 4 to afford 2 which by a palladium mediated coupling with 3, delivered SB 222618 (1) in good yield. (C) 2000 Elsevier Science Ltd.

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Conde, J. J., & Mendelson, W. (2000). Synthesis of SB 222618. A potential PDE IV inhibitor. Tetrahedron Letters, 41(6), 811–814. https://doi.org/10.1016/S0040-4039(99)02198-X

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