Synthesis, structure, and antimycobacterial activity of 6-[1(3H)-isobenzofuranylidenemethyl]purines and analogs

  • Brændvang M
  • Bakken V
  • Gundersen L
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Abstract

6-Benzofuryl-, styryl, benzyl, and furfurylpurines as well as 6-[1(3H)-isobenzofuranylidenemethyl]purines have been synthesized and their activities against Mycobacterium tuberculosis (Mtb) determined. Several compounds displayed profound antimycobacterial activity in combination with low toxicity towards mammalian cells. NMR and X-ray crystallography were employed to determine the detailed structures and the results were supported by quantum chemical calculations. © 2009 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • Ab initio calculations
  • Antimycobacterials
  • Cross-couplings
  • Purines
  • X-ray

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Authors

  • Morten Brændvang

  • Vebjørn Bakken

  • Lise Lotte Gundersen

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