Conversion of aflatoxin B1to its demethylated derivative, aflatoxin P1, has been achieved by treatment of the parent substance with lithium t-butylmercaptide in hexamethyl phosphoramide for 2 hours at 75°C. A preliminary toxicologic evaluation in newborn mice showed aflatoxin P1to cause some mortality at 150 mg/kg, whereas aflatoxin B1had an LD5 0of 9.5 mg/kg under comparable conditions. © 1973.
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