Synthesis and toxicity evaluation of aflatoxin P1

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Abstract

Conversion of aflatoxin B1to its demethylated derivative, aflatoxin P1, has been achieved by treatment of the parent substance with lithium t-butylmercaptide in hexamethyl phosphoramide for 2 hours at 75°C. A preliminary toxicologic evaluation in newborn mice showed aflatoxin P1to cause some mortality at 150 mg/kg, whereas aflatoxin B1had an LD5 0of 9.5 mg/kg under comparable conditions. © 1973.

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Buchi, G., Spitzner, D., Paglialunga, S., & Wogan, G. N. (1973). Synthesis and toxicity evaluation of aflatoxin P1. Life Sciences, 13(8), 1143–1149. https://doi.org/10.1016/0024-3205(73)90381-0

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