Synthesis and toxicity evaluation of aflatoxin P1

  • Buchi G
  • Spitzner D
  • Paglialunga S
 et al. 
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Abstract

Conversion of aflatoxin B1to its demethylated derivative, aflatoxin P1, has been achieved by treatment of the parent substance with lithium t-butylmercaptide in hexamethyl phosphoramide for 2 hours at 75°C. A preliminary toxicologic evaluation in newborn mice showed aflatoxin P1to cause some mortality at 150 mg/kg, whereas aflatoxin B1had an LD5 0of 9.5 mg/kg under comparable conditions. © 1973.

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Authors

  • G. Buchi

  • D. Spitzner

  • S. Paglialunga

  • G. N. Wogan

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