Synthesis of uracil polyoxin C from uridine

  • Evina C
  • Guillerm G
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Abstract

An improved procedure is reported for the asymmetric synthesis of uracil polyoxin C (UPOC) from 2',3'-O-isopropylideneuridine-5'-aldehyde. The methodology described here is based on the highly diastereocontrolled formation of 1-(β-D-allofuranosyl)uracil and its facile conversion into the corresponding 2,5'-O-cyclouridine derivative, a key step for the stereocontrolled formation of the terminal α-amino acid of UPOC.

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Authors

  • Claude Mvondo Evina

  • Georges Guillerm

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