Towards an optimal drug-delivery regimen for methotrexate chemotherapy

  • Nathanson M
  • Hillman R
  • Georgakis C
  • 1

    Readers

    Mendeley users who have this article in their library.
  • 1

    Citations

    Citations of this article.

Abstract

To date, drug regimes for cancer chemotherapy have been developed on empirical bases. In this work the desired distribution of a certain drug, methotrexate, is specified a priori. Then a drug regimen is developed which most nearly attains this distribution. The regimen is designed to attain certain quantitative therapeutic measures (i.e. maximum tumor-cell damage with minimum normal-cell damage). Although the procedure is a general one, we have chosen the drug methotrexate to illustrate the principles. © 1983.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • M. H. Nathanson

  • R. S. Hillman

  • C. Georgakis

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free