To date, drug regimes for cancer chemotherapy have been developed on empirical bases. In this work the desired distribution of a certain drug, methotrexate, is specified a priori. Then a drug regimen is developed which most nearly attains this distribution. The regimen is designed to attain certain quantitative therapeutic measures (i.e. maximum tumor-cell damage with minimum normal-cell damage). Although the procedure is a general one, we have chosen the drug methotrexate to illustrate the principles. © 1983.
Nathanson, M. H., Hillman, R. S., & Georgakis, C. (1983). Towards an optimal drug-delivery regimen for methotrexate chemotherapy. Applied Mathematics and Computation, 12(2–3), 99–117. https://doi.org/10.1016/0096-3003(83)90002-4