A synthetic approach to a new class of microtubule-stabilizing natural products is described which employs a macrocyclic olefination strategy to cyclize the 16-membered lactone ring. The C13-C19 thiazole subunit of epothilone A and B is prepared in high enantioselectivity using a catalytic asymmetric allylation reaction.
Taylor, R. E., & Haley, J. D. (1997). Towards the synthesis of epothilone A: Enantioselective preparation of the thiazole side-chain and macrocyclic ring closure. Tetrahedron Letters, 38(12), 2061–2064. https://doi.org/10.1016/S0040-4039(97)00285-2