A strain of reticuloendotheliosis virus-infected chicken embryo fibroblasts has been isolated and found to be transformed by the following criteria: (1) altered morphology, (2) increased cell density, (3) increased passage capability, (4) growth in soft agar, (5) increased uptake of 2-deoxy-D-glucose, and (6) tumorigenicity. Detectable avian leukosis-sarcoma viruses are not produced by these cells. © 1977.
Franklin, R. B., Kang, C. Y., Min-Min Wan, K., & Bose, H. R. (1977). Transformation of chick embryo fibroblasts by reticuloendotheliosis virus. Virology, 83(2), 313–321. https://doi.org/10.1016/0042-6822(77)90176-3