A short transient rise of cyclic AMP is observed within 1 minute after primary stimulation of neutrophils with chemotactic serum peptides containing classical anaphylatoxin (CAT). A second administration of these peptides after two minutes failed to produce a second peak of cAMP. Human serum albumin [HSA] which has chemokinetic but no chemotactic activities did not change cAMP levels. There was no significant change in cGMP levels within 1 minute following stimulation of rabbit neutrophils with chemotactic peptides or HSA. © 1979.
Keller, H. U., Gerisch, G., & Wissler, J. H. (1979). A transient rise in cyclic AMP levels following chemotactic stimulation of neutrophil granulocytes. Cell Biology International Reports, 3(9), 759–765. https://doi.org/10.1016/0309-1651(79)90082-1