Transport of the antibacterial agent (6S)-6-fluoroshikimate and other shikimate analogues by the shikimate transport system of Escherichia coli

  • Jude D
  • Ewart C
  • Thain J
 et al. 
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Abstract

We show that the antibacterial agent, (6S)-6-fluoroshikimate, is a substrate for the shikimate transport system of Escherichia coli because in exchange-diffusion experiments it displaced intracellular [14C]shikimate with the same kinetics as did unlabelled shikimate. Other shikimate analogues were also substrates: as judged by similar experiments or, in the case of (6R)-6-fluoroshikimate, by inference.

Author-supplied keywords

  • Antibacterial agent
  • Fluoroshikimate
  • Shikimate transport
  • shiA

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Authors

  • David A. Jude

  • Christopher D.C. Ewart

  • John L. Thain

  • Gareth M. Davies

  • Wright W. Nichols

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