Trauma-induced increase of extracellular ascorbate in rat cerebral cortex

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Extracellular (EC) ascorbate concentrations were measured in microdialysates from the cerebral cortex in rats subjected to cortical compression-contusion trauma. The trauma induced a transient, dramatic increase in EC ascorbate compared to the basal level before the insult and compared to control animals. The data support the presence of a releasable intracellular pool of ascorbate in the neocortex. The possibility that ascorbate may influence traumatic brain damage by its proposed neuromodulatory property and/or by its ability to induce lipid peroxidation is considered. © 1990.




Hillered, L., Nilsson, P., Ungerstedt, U., & Pontén, U. (1990). Trauma-induced increase of extracellular ascorbate in rat cerebral cortex. Neuroscience Letters, 113(3), 328–332.

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