Trauma-induced increase of extracellular ascorbate in rat cerebral cortex

  • Hillered L
  • Nilsson P
  • Ungerstedt U
 et al. 
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Abstract

Extracellular (EC) ascorbate concentrations were measured in microdialysates from the cerebral cortex in rats subjected to cortical compression-contusion trauma. The trauma induced a transient, dramatic increase in EC ascorbate compared to the basal level before the insult and compared to control animals. The data support the presence of a releasable intracellular pool of ascorbate in the neocortex. The possibility that ascorbate may influence traumatic brain damage by its proposed neuromodulatory property and/or by its ability to induce lipid peroxidation is considered. © 1990.

Author-supplied keywords

  • Ascorbic acid
  • Brain
  • Microdialysis
  • Rat
  • Trauma

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Authors

  • Lars Hillered

  • Pelle Nilsson

  • Urban Ungerstedt

  • Urban Pontén

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