Trichothecinols A, B and C, potent anti-tumor, promoting sesquiterpenoids from the fungus Trichothecium roseum

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Abstract

Three new trichothecenes, trichothecinols A (1), B (2) and C (3) were isolated from the fungus Trichothecium roseum and unambiguiously characterized on the basis of spectroscopic and chemical evidence. These exhibited potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).

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Iida, A., Konishi, K., Kubo, H., Tomioka, K., Tokuda, H., & Nishino, H. (1996). Trichothecinols A, B and C, potent anti-tumor, promoting sesquiterpenoids from the fungus Trichothecium roseum. Tetrahedron Letters, 37(51), 9219–9220. https://doi.org/10.1016/S0040-4039(96)02187-9

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