Uncoupling of CA3 pyramidal neurons by propionate

  • MacVicar B
  • Jahnsen H
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Abstract

The influence of cytoplasmic acidification on dye-coupling between CA3 pyramidal neurons was examined by Lucifer yellow injections in guinea pig hippocampal brain slice. Neurons were believed to be acidified by exposure to 100 mM propionate. Dye-coupling was reduced significantly to 6% (n = 35) in propionate versus 28% (n = 39) in control solution (P < 2 %). Propionate may be a useful tool for experimental manipulation of coupling in the mammalian CNS. © 1985.

Author-supplied keywords

  • electrotonic coupling
  • hippocampus pyramidal neurons
  • propionate
  • uncoupling

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