Utility and quality of autologous fresh frozen plasma and autologous fibrin glue for surgical patients

  • Komatsu F
  • Yoshida S
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Abstract

The quality of autologous fresh frozen plasma and autologous fibrin glue prepared in our hospital was evaluated. The Auto-FFP was separated from whole blood or collected using a cell separator and the Auto-FG was then prepared from the Auto-FFP. The Auto-FFP showed significantly higher levels of fibrinogen, Factor-V and Factor-VIII than commercially available FFP. The Auto-FG contained approximately 10 times the concentration of fibrinogen, Factor-VIII, Factor-XIII, von Willbrand factor and fibronectin and 1.5 times that of α2-Plasminogen inhibitor compared to those of the Auto-FFP. When the Auto-FG was sprayed over diffusely bleeding sites from surgical wounds, hemostasis occurred within 5 s. These results suggest that Auto-FFP and Auto- FG may have sufficient utility and quality to reduce the use of allogeneic blood products.

Author-supplied keywords

  • Autologous blood product
  • Coagulation factor
  • Fibrin glue
  • Fresh frozen plasma

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Authors

  • Fumio Komatsu

  • Sayaka Yoshida

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