The quality of autologous fresh frozen plasma and autologous fibrin glue prepared in our hospital was evaluated. The Auto-FFP was separated from whole blood or collected using a cell separator and the Auto-FG was then prepared from the Auto-FFP. The Auto-FFP showed significantly higher levels of fibrinogen, Factor-V and Factor-VIII than commercially available FFP. The Auto-FG contained approximately 10 times the concentration of fibrinogen, Factor-VIII, Factor-XIII, von Willbrand factor and fibronectin and 1.5 times that of α2-Plasminogen inhibitor compared to those of the Auto-FFP. When the Auto-FG was sprayed over diffusely bleeding sites from surgical wounds, hemostasis occurred within 5 s. These results suggest that Auto-FFP and Auto- FG may have sufficient utility and quality to reduce the use of allogeneic blood products.
Komatsu, F., & Yoshida, S. (1999). Utility and quality of autologous fresh frozen plasma and autologous fibrin glue for surgical patients. Transfusion Science, 21(2), 105–109. https://doi.org/10.1016/S0955-3886(99)00080-6