Vaccination of pigs against pseudorabies virus with plasmid DNA encoding glycoprotein D

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Abstract

We analysed the ability of a plasmid carrying the gene encoding glycoprotein D (gD) of pseudorabies virus (PRV) to induce humoral and cell- mediated immune responses and assessed the protection provided by PRV-gD DNA vaccination against challenge infection with PRV. Immunization with plasmid PRV-gD induced neutralizing antibodies and lymphocyte proliferative responses both in mice and pigs. Moreover, when challenged with virulent PRV six weeks following the last immunization, PRV-gD DNA vaccinated pigs excreted virus for a significantly shorter period and showed less clinical symptoms than pigs vaccinated with a control plasmid. Thus, in the target animal, DNA vaccination with PRV-gD DNA induces protective immunity against challenge infection.

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Haagmans, B. L., Van Rooij, E. M. A., Dubelaar, M., Kimman, T. G., Horzinek, M. C., Schijns, V. E. C. J., & Bianchi, A. T. J. (1999). Vaccination of pigs against pseudorabies virus with plasmid DNA encoding glycoprotein D. Vaccine, 17(9–10), 1264–1271. https://doi.org/10.1016/S0264-410X(98)00349-1

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