Vasoconstriction induced by inhalation of irritant vapour is associated with appearance of Fos protein in C1 catecholamine neurons in rabbit medulla oblongata

  • Gieroba Z
  • Yu Y
  • Blessing W
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Abstract

The medulla oblongata was examined with Fos and tyrosine hydroxylase (TH) immunohistochemistry after 2 h of intermittent nasopharyngeal stimulation with formaldehyde vapour in the conscious rabbit. The stimulation caused apnoea, bradycardia and a rise in blood pressure known to be associated with vigorous vasocontriction. Fos-positive neurons occurred in the spinal trigeminal nucleus, the nucleus tractus solitarius, the raphe nuclei and the ventrolateral medulla. In the rostral ventolateral medulla, 68% of the Fos-positive neurons were TH-positive C1 cells. Our data indicate that nasopharyngeally-evoked peripheral vasoconstriction is associated with activation of C1 neurons. © 1994.

Author-supplied keywords

  • Arterial pressure
  • Nasopharyngeal reflex
  • Rostral ventrolateral medulla
  • Spinal trigeminal nucleus
  • Tyrosine hydroxylase
  • c-fos

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