The medulla oblongata was examined with Fos and tyrosine hydroxylase (TH) immunohistochemistry after 2 h of intermittent nasopharyngeal stimulation with formaldehyde vapour in the conscious rabbit. The stimulation caused apnoea, bradycardia and a rise in blood pressure known to be associated with vigorous vasocontriction. Fos-positive neurons occurred in the spinal trigeminal nucleus, the nucleus tractus solitarius, the raphe nuclei and the ventrolateral medulla. In the rostral ventolateral medulla, 68% of the Fos-positive neurons were TH-positive C1 cells. Our data indicate that nasopharyngeally-evoked peripheral vasoconstriction is associated with activation of C1 neurons. © 1994.
Gieroba, Z. J., Yu, Y. H., & Blessing, W. W. (1994). Vasoconstriction induced by inhalation of irritant vapour is associated with appearance of Fos protein in C1 catecholamine neurons in rabbit medulla oblongata. Brain Research, 636(1), 157–161. https://doi.org/10.1016/0006-8993(94)90192-9