Vasoconstriction induced by inhalation of irritant vapour is associated with appearance of Fos protein in C1 catecholamine neurons in rabbit medulla oblongata

  • Gieroba Z
  • Yu Y
  • Blessing W
  • 5


    Mendeley users who have this article in their library.
  • 24


    Citations of this article.


The medulla oblongata was examined with Fos and tyrosine hydroxylase (TH) immunohistochemistry after 2 h of intermittent nasopharyngeal stimulation with formaldehyde vapour in the conscious rabbit. The stimulation caused apnoea, bradycardia and a rise in blood pressure known to be associated with vigorous vasocontriction. Fos-positive neurons occurred in the spinal trigeminal nucleus, the nucleus tractus solitarius, the raphe nuclei and the ventrolateral medulla. In the rostral ventolateral medulla, 68% of the Fos-positive neurons were TH-positive C1 cells. Our data indicate that nasopharyngeally-evoked peripheral vasoconstriction is associated with activation of C1 neurons. © 1994.

Author-supplied keywords

  • Arterial pressure
  • Nasopharyngeal reflex
  • Rostral ventrolateral medulla
  • Spinal trigeminal nucleus
  • Tyrosine hydroxylase
  • c-fos

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free