Ventilation, EELV and diaphragmatic activity in rats during chronic normobaric hypoxia

  • Vizek M
  • Bonora M
  • 4


    Mendeley users who have this article in their library.
  • 5


    Citations of this article.


We determined the effects of chronic hypoxia on end-expiratory lung volume (EELV), end-expiratory diaphragmatic activity (DE) and ventilation (V̇E) in 27 intact (awake and anesthetized) and six carotid body-denervated (CBD; anesthetized) rats. Twenty-nine control animals were also studied. Recordings were made during hypoxia and normoxia before and after 2 or 3 weeks of hypoxia (+3 days of recovery from chronic hypoxia). In awake rats, 2 weeks of chronic hypoxia increased only normoxic V̇E, while 3 weeks of chronic hypoxia did not change V̇E or DE. In anesthetized intact rats, after both exposures, hypoxic and normoxic V̇E tended to decrease, DE did not change and hypoxic and normoxic EELV were enlarged. In CBD animals, 2 weeks of chronic hypoxia did not affect hypoxic V̇E but decreased normoxic ventilation and enlarged EELV similar to the intact animals. After 3 days of recovery in normoxia, all parameters except EELV were restored to prehypoxic values. Also, transition from hypoxia to normoxia induced parallel changes in EELV and DE while chronic hypoxia increased only EELV. Therefore, chronic normobaric hypoxia induced, (1) an increase in normoxic ventilation reflecting a process of acclimatization; (2) an enlargement of EELV that did not depend on changes in DE and carotid chemoreceptors. © 2001 Elsevier Science B.V. All rights reserved.

Author-supplied keywords

  • Carotid body, denervation
  • Control of breathing, hypoxia, end-expiratory lung volume
  • Hypoxia, chronic, end-expiratory lung volume
  • Mammals, rat
  • Pattern of breathing, hypoxia
  • Volume, lung, end-expiratory, hypoxia

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Martin Vizek

  • Monique Bonora

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free