Treatment of bone marrow progenitor cells (BMPC) with zidovudine (AZT) at various concentrations (0.5 to 20 muM) in vitro for 24 hr caused a concentration-dependent decrease in erythropoietin (Epo) receptor expression. The decrease in Epo receptors correlated with a decline in mRNA levels of the receptor. These results suggest that AZT-induced down-regulation of Epo receptor expression followed by loss of Epo-receptor mediated signal transduction is a significant contributory factor to AZT-induced erythroid toxicity. © 1992.
Gogu, S. R., Malter, J. S., & Agrawal, K. C. (1992). Zidovudine-induced blockade of the expression and function of the erythropoietin receptor. Biochemical Pharmacology, 44(6), 1009–1012. https://doi.org/10.1016/0006-2952(92)90361-L