Zidovudine-induced blockade of the expression and function of the erythropoietin receptor

  • Gogu S
  • Malter J
  • Agrawal K
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Treatment of bone marrow progenitor cells (BMPC) with zidovudine (AZT) at various concentrations (0.5 to 20 muM) in vitro for 24 hr caused a concentration-dependent decrease in erythropoietin (Epo) receptor expression. The decrease in Epo receptors correlated with a decline in mRNA levels of the receptor. These results suggest that AZT-induced down-regulation of Epo receptor expression followed by loss of Epo-receptor mediated signal transduction is a significant contributory factor to AZT-induced erythroid toxicity. © 1992.

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  • Sudhir R. Gogu

  • James S. Malter

  • Krishna C. Agrawal

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