Zidovudine-induced blockade of the expression and function of the erythropoietin receptor

17Citations
Citations of this article
3Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Treatment of bone marrow progenitor cells (BMPC) with zidovudine (AZT) at various concentrations (0.5 to 20 muM) in vitro for 24 hr caused a concentration-dependent decrease in erythropoietin (Epo) receptor expression. The decrease in Epo receptors correlated with a decline in mRNA levels of the receptor. These results suggest that AZT-induced down-regulation of Epo receptor expression followed by loss of Epo-receptor mediated signal transduction is a significant contributory factor to AZT-induced erythroid toxicity. © 1992.

Cite

CITATION STYLE

APA

Gogu, S. R., Malter, J. S., & Agrawal, K. C. (1992). Zidovudine-induced blockade of the expression and function of the erythropoietin receptor. Biochemical Pharmacology, 44(6), 1009–1012. https://doi.org/10.1016/0006-2952(92)90361-L

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free