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Tsuyoshi Miyakawa profile photo

Tsuyoshi Miyakawa, Ph. D.

Professor, Fujita Health University
Toyoake, Japan

Research field: Biological Sciences
Biological basis of schizophrenia
Dentate gyrus
Relationships between genes and behavior


Awards and Grants

  •  Oct 2007 
    JST, CREST View website
  •  Jan 2001 
    NARSAD Young Investigator Award

Biographical Information

I have been trying to find animal model of psychiatric disorders by using, what we call, a comprehensive behavioral tests battery on mutant mice. During these 17 years, I have looked at more nearly 140 strains of mutant mice, like knockout mice or transgenic mice. So far we have identified several different mice models of schizophrenia/bipolar disorders. Among them are forebrain calcineurin knockout mice and alpha-CaMKII HKO mice (Zeng et al., Cell, 2001; Miyakawa et al., PNAS, 2003; Gerber et al., PNAS, 2003; Yamasaki et al., Molecular Brain, 2008). We are also trying to find what's going on in the brains of those mice model of psychiatric disorders using a variety of techniques such as gene ship analysis, proteome analysis, neural activity mapping using c-Fos or Arc, electrophysiological analyses and etc.
Sar far, we have found a remarkable phenotype in the hippocampus of the brain, which I named, "immature Dentate Gyrus (=iDG)" (Yamasaki et al., Molecular Brain, 2008; Matsuo et al., Frontiers in Behavioral Neuroscience, 2009). In iDG of those animals, most of the DG neurons fail to mature and stay immature, even after the mice become adults.
We realized that this iDG phenotype is quite common among the mice showing hyperactivity and working memory deficit.
Interestingly, chronic treatment of Fluoxetine, a SSRI type of anti-depressants, can also cause iDG in normal B6 mice. We call it "dematuration" (Kobayashi et al, PNAS, 2010).


Professional Experience

2007 - Present
Professor at Fujita Health University
Toyoake, Japan

1997 - Present
University of Tokyo in Tōkyō, Japan
Ph. D.

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Toyoake, Japan
Main City

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