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Tsuyoshi Miyakawa

  • Ph. D.
  • Professor
  • Fujita Health University
  • 44h-indexImpact measure calculated using publication and citation counts. Updated daily.
  • 7770CitationsNumber of citations received by Tsuyoshi's publications. Updated daily.

Other IDs

Research interests

Biological basis of schizophrenia Dentate gyrus Relationships between genes and behavior


I have been trying to find animal model of psychiatric disorders by using, what we call, a comprehensive behavioral tests battery on mutant mice. During these 17 years, I have looked at more nearly 140 strains of mutant mice, like knockout mice or transgenic mice. So far we have identified several different mice models of schizophrenia/bipolar disorders. Among them are forebrain calcineurin knockout mice and alpha-CaMKII HKO mice (Zeng et al., Cell, 2001; Miyakawa et al., PNAS, 2003; Gerber et al., PNAS, 2003; Yamasaki et al., Molecular Brain, 2008). We are also trying to find what's going on in the brains of those mice model of psychiatric disorders using a variety of techniques such as gene ship analysis, proteome analysis, neural activity mapping using c-Fos or Arc, electrophysiological analyses and etc. Sar far, we have found a remarkable phenotype in the hippocampus of the brain, which I named, "immature Dentate Gyrus (=iDG)" (Yamasaki et al., Molecular Brain, 2008; Matsuo et al., Frontiers in Behavioral Neuroscience, 2009). In iDG of those animals, most of the DG neurons fail to mature and stay immature, even after the mice become adults. We realized that this iDG phenotype is quite common among the mice showing hyperactivity and working memory deficit. Interestingly, chronic treatment of Fluoxetine, a SSRI type of anti-depressants, can also cause iDG in normal B6 mice. We call it "dematuration" (Kobayashi et al, PNAS, 2010).

Co-authors (783)

Publications (5)

  • Abnormalities in perineuronal nets and behavior in mice lacking CSGalNAcT1, a key enzyme in chondroitin sulfate synthesis

    • Yoshioka N
    • Miyata S
    • Tamada A
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  • Comprehensive behavioral analysis of activating transcription factor 5-deficient mice

    • Umemura M
    • Ogura T
    • Matsuzaki A
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  • Transcriptomic immaturity of the hippocampus and prefrontal cortex in patients with alcoholism

    • Murano T
    • Koshimizu H
    • Hagihara H
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  • Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism

    • Shimohata A
    • Ishihara K
    • Hattori S
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  • Correction: Genomic responses in mouse models greatly mimic human inflammatory diseases (Proceedings of the National Academy of Sciences of the United States of America (2014) 112, 4 (1167-1172) DOI: 10.1073/pnas.1401965111)

    • Takao K
    • Miyakawa T
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Professional experience


Fujita Health University

April 2007 - Present

Education history

Ph. D.

University of Tokyo

March 1997 - Present