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Tsuyoshi Miyakawa

  • Ph. D.
  • Professor
  • Fujita Health University
  • 43h-indexImpact measure calculated using publication and citation counts. Updated daily.
  • 8054CitationsNumber of citations received by Tsuyoshi's publications. Updated daily.

Other IDs

Research interests

Biological basis of schizophrenia Dentate gyrus Relationships between genes and behavior

About

I have been trying to find animal model of psychiatric disorders by using, what we call, a comprehensive behavioral tests battery on mutant mice. During these 17 years, I have looked at more nearly 140 strains of mutant mice, like knockout mice or transgenic mice. So far we have identified several different mice models of schizophrenia/bipolar disorders. Among them are forebrain calcineurin knockout mice and alpha-CaMKII HKO mice (Zeng et al., Cell, 2001; Miyakawa et al., PNAS, 2003; Gerber et al., PNAS, 2003; Yamasaki et al., Molecular Brain, 2008). We are also trying to find what's going on in the brains of those mice model of psychiatric disorders using a variety of techniques such as gene ship analysis, proteome analysis, neural activity mapping using c-Fos or Arc, electrophysiological analyses and etc. Sar far, we have found a remarkable phenotype in the hippocampus of the brain, which I named, "immature Dentate Gyrus (=iDG)" (Yamasaki et al., Molecular Brain, 2008; Matsuo et al., Frontiers in Behavioral Neuroscience, 2009). In iDG of those animals, most of the DG neurons fail to mature and stay immature, even after the mice become adults. We realized that this iDG phenotype is quite common among the mice showing hyperactivity and working memory deficit. Interestingly, chronic treatment of Fluoxetine, a SSRI type of anti-depressants, can also cause iDG in normal B6 mice. We call it "dematuration" (Kobayashi et al, PNAS, 2010).

Groups

Co-authors (799)

Publications (5)

  • Comprehensive behavioral analysis of the Cdkl5 knockout mice revealed significant enhancement in anxiety- and fear-related behaviors and impairment in both acquisition and long-term retention of spatial reference memory

    • Okuda K
    • Takao K
    • Watanabe A
    • et al.
    N/AReaders
    0Citations
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  • Decreased Brain pH as a Shared Endophenotype of Psychiatric Disorders

    • Hagihara H
    • Catts V
    • Katayama Y
    • et al.
    N/AReaders
    1Citations
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  • Immature morphological properties in subcellular-scale structures in the dentate gyrus of Schnurri-2 knockout mice: A model for schizophrenia and intellectual disability

    • Nakao A
    • Miyazaki N
    • Ohira K
    • et al.
    N/AReaders
    0Citations
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  • Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease: analysis of Osaka mutation-knockin mice

    • Umeda T
    • Kimura T
    • Yoshida K
    • et al.
    N/AReaders
    0Citations
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  • Distribution of Silver Nanoparticles to Breast Milk and Their Biological Effects on Breast-Fed Offspring Mice

    • Morishita Y
    • Yoshioka Y
    • Takimura Y
    • et al.
    N/AReaders
    9Citations
    Get full text

Professional experience

Professor

Fujita Health University

April 2007 - Present

Education

Ph. D.

University of Tokyo

March 1997 - Present