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Tsuyoshi Miyakawa

  • Ph. D.
  • Professor
  • Fujita Health University
41

h-index

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6451

Citations

Number of citations received by these publications in Scopus.

Research Interests

Biological basis of schizophrenia Dentate gyrus Relationships between genes and behavior

Followers (2)

Following (1)

About

I have been trying to find animal model of psychiatric disorders by using, what we call, a comprehensive behavioral tests battery on mutant mice. During these 17 years, I have looked at more nearly 140 strains of mutant mice, like knockout mice or transgenic mice. So far we have identified several different mice models of schizophrenia/bipolar disorders. Among them are forebrain calcineurin knockout mice and alpha-CaMKII HKO mice (Zeng et al., Cell, 2001; Miyakawa et al., PNAS, 2003; Gerber et al., PNAS, 2003; Yamasaki et al., Molecular Brain, 2008). We are also trying to find what's going on in the brains of those mice model of psychiatric disorders using a variety of techniques such as gene ship analysis, proteome analysis, neural activity mapping using c-Fos or Arc, electrophysiological analyses and etc.
Sar far, we have found a remarkable phenotype in the hippocampus of the brain, which I named, "immature Dentate Gyrus (=iDG)" (Yamasaki et al., Molecular Brain, 2008; Matsuo et al., Frontiers in Behavioral Neuroscience, 2009). In iDG of those animals, most of the DG neurons fail to mature and stay immature, even after the mice become adults.
We realized that this iDG phenotype is quite common among the mice showing hyperactivity and working memory deficit.
Interestingly, chronic treatment of Fluoxetine, a SSRI type of anti-depressants, can also cause iDG in normal B6 mice. We call it "dematuration" (Kobayashi et al, PNAS, 2010).

Publications

Age-related changes in behavior in C57BL/6J mice from young adulthood to middle age

Shoji H, Takao K, Hattori S, Miyakawa T

Molecular Brain (2016)

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Circadian Gene Circuitry Predicts Hyperactive Behavior in a Mood Disorder Mouse Model

Hagihara H, Horikawa T, Nakamura H, Umemori J, Shoji H, Kamitani Y, Miyakawa T

Cell Reports (2016)

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Comprehensive behavioral phenotyping of a new Semaphorin 3 F mutant mouse

Matsuda I, Shoji H, Yamasaki N, Miyakawa T, Aiba A

Molecular Brain (2016)

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Comprehensive behavioral analysis of voltage-gated calcium channel beta-anchoring and -regulatory protein knockout mice

Nakao A, Miki T, Shoji H, Nishi M, Takeshima H, Miyakawa T, Mori Y

Frontiers in Behavioral Neuroscience (2015)

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Genomic responses in mouse models greatly mimic human inflammatory diseases

Takao K, Miyakawa T

Proceedings of the National Academy of Sciences of the United States of America (2015)

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Professional experience

Professor

Fujita Health University

April 2007 - Present

Education history

University of Tokyo

Ph. D.

March 1997 - Present