Tsuyoshi Miyakawa Ph. D.

Professor

Fujita Health University

Location
Toyoake, Japan
Discipline
Biological Sciences
Interests
Biological basis of schizophrenia Dentate gyrus Relationships between genes and behavior
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Followers (2)

Following (1)

About

I have been trying to find animal model of psychiatric disorders by using, what we call, a comprehensive behavioral tests battery on mutant mice. During these 17 years, I have looked at more nearly 140 strains of mutant mice, like knockout mice or transgenic mice. So far we have identified several different mice models of schizophrenia/bipolar disorders. Among them are forebrain calcineurin knockout mice and alpha-CaMKII HKO mice (Zeng et al., Cell, 2001; Miyakawa et al., PNAS, 2003; Gerber et al., PNAS, 2003; Yamasaki et al., Molecular Brain, 2008). We are also trying to find what's going on in the brains of those mice model of psychiatric disorders using a variety of techniques such as gene ship analysis, proteome analysis, neural activity mapping using c-Fos or Arc, electrophysiological analyses and etc.
Sar far, we have found a remarkable phenotype in the hippocampus of the brain, which I named, "immature Dentate Gyrus (=iDG)" (Yamasaki et al., Molecular Brain, 2008; Matsuo et al., Frontiers in Behavioral Neuroscience, 2009). In iDG of those animals, most of the DG neurons fail to mature and stay immature, even after the mice become adults.
We realized that this iDG phenotype is quite common among the mice showing hyperactivity and working memory deficit.
Interestingly, chronic treatment of Fluoxetine, a SSRI type of anti-depressants, can also cause iDG in normal B6 mice. We call it "dematuration" (Kobayashi et al, PNAS, 2010).
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Publications

T-maze Forced Alternation and Left-right Discrimination Tasks for Assessing Working and Reference Memory in Mice

Shoji H, Hagihara H, Takao K, Hattori S, Miyakawa T

Journal of Visualized Experiments (2012)

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Adenomatous polyposis coli heterozygous knockout mice display hypoactivity and age-dependent working memory deficits

Koshimizu H, Takao K, Ohira K, Tanda K, Nakanishi K, Toyama K et al.

Frontiers in Behavioral Neuroscience (2011)

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DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze

Asrar S, Kaneko K, Takao K, Negandhi J, Matsui M, Shibasaki K et al.

Molecular Brain (2011)

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P301S Mutant Human Tau Transgenic Mice Manifest Early Symptoms of Human Tauopathies with Dementia and Altered Sensorimotor Gating

Takeuchi H, Iba M, Inoue H, Higuchi M, Takao K, Tsukita K et al.

PLoS ONE (2011)

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Forebrain-specific constitutively active CaMKKα transgenic mice show deficits in hippocampus-dependent long-term memory

Kaitsuka T, Li S, Nakamura K, Takao K, Miyakawa T, Matsushita M

Neurobiology of Learning and Memory (2011)

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Synaptic E3 Ligase SCRAPPER in Contextual Fear Conditioning: Extensive Behavioral Phenotyping of Scrapper Heterozygote and Overexpressing Mutant Mice

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The Influence of Chronic Cerebral Hypoperfusion on Cognitive Function and Amyloid β Metabolism in APP Overexpressing Mice

Yamada M, Ihara M, Okamoto Y, Maki T, Washida K, Kitamura A et al.

PLoS ONE (2011)

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Chronic treatment with fluoxetine for more than 6 weeks decreases neurogenesis in the subventricular zone of adult mice

Ohira K, Miyakawa T

Molecular Brain (2011)

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Relaxin-3-deficient mice showed slight alteration in anxiety-related behavior

Tsujimura A, Nishi K, Yokoyama C, Miyakawa T, Tanaka M

Frontiers in Behavioral Neuroscience (2011)

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Expression of the AMPA Receptor Subunits GluR1 and GluR2 is Associated with Granule Cell Maturation in the Dentate Gyrus

Hagihara H, Ohira K, Toyama K, Miyakawa T

Frontiers in Neurogenesis (2011)

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Behavioral profiles of three C57BL/6 substrains

Matsuo N, Takao K, Nakanishi K, Yamasaki N, Tanda K, Miyakawa T

Frontiers in Behavioral Neuroscience (2010)

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Dissection of hippocampal dentate gyrus from adult mouse.

Hagihara H, Toyama K, Yamasaki N, Miyakawa T

Journal of visualized experiments JoVE (2009)

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Reversal of hippocampal neuronal maturation by serotonergic antidepressants

Kobayashi K, Ikeda Y, Sakai A, Yamasaki N, Haneda E, Miyakawa T et al.

Proceedings of the National Academy of Sciences of the United States of America (2010)

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SDOP-DB: A comparative standardised-protocol database for mouse phenotypic analyses

Tanaka N, Waki K, Kaneda H, Suzuki T, Yamada I, Furuse T et al.

Bioinformatics (Oxford, England) (2010)

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Comprehensive Behavioral Analysis of Calcium/Calmodulin-Dependent Protein Kinase IV Knockout Mice

Takao K, Tanda K, Nakamura K, Kasahara J, Nakao K, Katsuki M et al.

PLoS ONE (2010)

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Ischemia-induced neurogenesis of neocortical layer 1 progenitor cells

Ohira K, Furuta T, Hioki H, Nakamura K, Kuramoto E, Tanaka Y et al.

Nat Neurosci (2009)

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Neural activity changes underlying the working memory deficit in alpha-CaMKII heterozygous knockout mice

Matsuo N, Yamasaki N, Ohira K, Takao K, Toyama K, Eguchi M et al.

Frontiers in Behavioral Neuroscience (2009)

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Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly

Yamada M, Yoshida Y, Mori D, Takitoh T, Kengaku M, Umeshima H et al.

Nat Med (2009)

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Mice with Altered Myelin Proteolipid Protein Gene Expression Display Cognitive Deficits Accompanied by Abnormal Neuron-Glia Interactions and Decreased Conduction Velocities

Tanaka H, Ma J, Tanaka K, Takao K, Komada M, Tanda K et al.

J. Neurosci. (2009)

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Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders

Yamasaki N, Maekawa M, Kobayashi K, Kajii Y, Maeda J, Soma M et al.

Molecular Brain (2008)

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Comprehensive behavioral phenotyping of calpastatin-knockout mice

Nakajima R, Takao K, Huang S, Takano J, Iwata N, Miyakawa T et al.

Molecular Brain (2008)

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Mice Lacking the kf-1 Gene Exhibit Increased Anxiety- but not Despair-Like Behavior

Tsujimura A, Matsuki M, Takao K, Yamanishi K, Miyakawa T, Hashimoto-Gotoh T

Frontiers in Behavioral Neuroscience (2008)

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Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity

Pang P, Teng H, Zaitsev E, Woo N, Sakata K, Zhen S et al.

Science (New York, N.Y.) (2004)

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脳神経科学イラストレイテッド

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Enhanced susceptibility of audiogenic seizures in Fyn-kinase deficient mice

Miyakawa T, Yagi T, Taniguchi M, Matsuura H, Tateishi K, Niki H

Brain research. Molecular brain research (1995)

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Radial maze performance, open-field and elevated plus-maze behaviors in Fyn-kinase deficient mice: further evidence for increased fearfulness

Miyakawa T, Yagi T, Kagiyama A, Niki H

Brain research. Molecular brain research (1996)

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Increased fearfulness of Fyn tyrosine kinase deficient mice

Miyakawa T, Yagi T, Watanabe S, Niki H

Brain research. Molecular brain research (1994)

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Susceptibility to drug-induced seizures of Fyn tyrosine kinase-deficient mice

Miyakawa T, Yagi T, Tateishi K, Niki H

Neuroreport (1996)

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Loss of cadherin-11 adhesion receptor enhances plastic changes in hippocampal synapses and modifies behavioral responses

Manabe T, Togashi H, Uchida N, Suzuki S, Hayakawa Y, Yamamoto M et al.

Molecular and cellular neurosciences (2000)

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Abnormal synaptic transmission in the olfactory bulb of Fyn-kinase-deficient mice

Kitazawa H, Yagi T, Miyakawa T, Niki H, Kawai N

Journal of neurophysiology (1998)

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Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function

Miyakawa T, Yagi T, Kitazawa H, Yasuda M, Kawai N, Tsuboi K et al.

Science (New York, N.Y.) (1997)

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Differential effect of Fyn tyrosine kinase deletion on offensive and defensive aggression

Miyakawa T, Yagi T, Takao K, Niki H

Behavioural brain research (2001)

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Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean

Yamada M, Miyakawa T, Duttaroy A, Yamanaka A, Moriguchi T, Makita R et al.

Nature (2001)

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Mice expressing only monosialoganglioside GM3 exhibit lethal audiogenic seizures

Kawai H, Allende M, Wada R, Kono M, Sango K, Deng C et al.

The Journal of biological chemistry (2001)

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Neurogranin null mutant mice display performance deficits on spatial learning tasks with anxiety related components

Miyakawa T, Yared E, Pak J, Huang F, Huang K, Crawley J

Hippocampus (2001)

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M1-M5 muscarinic receptor knockout mice as novel tools to study the physiological roles of the muscarinic cholinergic system

Wess J, Duttaroy A, Zhang W, Gomeza J, Cui Y, Miyakawa T et al.

Receptors & channels (2003)

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Forebrain-specific calcineurin knockout selectively impairs bidirectional synaptic plasticity and working/episodic-like memory

Zeng H, Chattarji S, Barbarosie M, Rondi-Reig L, Philpot B, Miyakawa T et al.

Cell (2001)

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Hyperactivity and intact hippocampus-dependent learning in mice lacking the M1 muscarinic acetylcholine receptor

Miyakawa T, Yamada M, Duttaroy A, Wess J

J Neurosci (2001)

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Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia

Miyakawa T, Leiter L, Gerber D, Gainetdinov R, Sotnikova T, Zeng H et al.

Proc Natl Acad Sci U S A (2003)

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Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit

Gerber D, Hall D, Miyakawa T, Demars S, Gogos J, Karayiorgou M et al.

Proc Natl Acad Sci U S A (2003)

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[Stress and animal model of psychiatric disease]

Miyakawa T, Yamasaki N

Nippon yakurigaku zasshi. Folia pharmacologica Japonica (2005)

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Tight junctions in Schwann cells of peripheral myelinated axons: a lesson from claudin-19-deficient mice

Miyamoto T, Morita K, Takemoto D, Takeuchi K, Kitano Y, Miyakawa T et al.

The Journal of cell biology (2005)

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Acceleration of visually cued conditioned fear through the auditory pathway

Newton J, Ellsworth C, Miyakawa T, Tonegawa S, Sur M

Nature neuroscience (2004)

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NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21

Arron J, Winslow M, Polleri A, Chang C, Wu H, Gao X et al.

Nature (2006)

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Investigating gene-to-behavior pathways in psychiatric disorders: the use of a comprehensive behavioral test battery on genetically engineered mice

Takao K, Miyakawa T

Annals of the New York Academy of Sciences (2006)

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Enhanced cocaine responsiveness and impaired motor coordination in metabotropic glutamate receptor subtype 2 knockout mice

Morishima Y, Miyakawa T, Furuyashiki T, Tanaka Y, Mizuma H, Nakanishi S

Proceedings of the National Academy of Sciences of the United States of America (2005)

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Enriched environments influence depression-related behavior in adult mice and the survival of newborn cells in their hippocampi

Hattori S, Hashimoto R, Miyakawa T, Yamanaka H, Maeno H, Wada K et al.

Behavioural brain research (2007)

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Mouse liaison for integrative brain research

Aiba A, Inokuchi K, Ishida Y, Itohara S, Kobayashi K, Masu M et al.

Neuroscience research (2007)

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Genetic ablation of NMDA receptor subunit NR3B in mouse reveals motoneuronal and nonmotoneuronal phenotypes

Niemann S, Kanki H, Fukui Y, Takao K, Fukaya M, Hynynen M et al.

The European journal of neuroscience (2007)

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Impact of brain-behavior phenotypying of genetically-engineered mice on research of neuropsychiatric disorders

Takao K, Yamasaki N, Miyakawa T

Neuroscience research (2007)

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Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity

Ihara M, Yamasaki N, Hagiwara A, Tanigaki A, Kitano A, Hikawa R et al.

Neuron (2007)

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Selective impairment of working memory in a mouse model of chronic cerebral hypoperfusion

Shibata M, Yamasaki N, Miyakawa T, Kalaria R, Fujita Y, Ohtani R et al.

Stroke; a journal of cerebral circulation (2007)

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Increased social interaction in mice deficient of the striatal medium spiny neuron-specific phosphodiesterase 10A2

Sano H, Nagai Y, Miyakawa T, Shigemoto R, Yokoi M

Journal of neurochemistry (2008)

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Smaller dendritic spines, weaker synaptic transmission, but enhanced spatial learning in mice lacking Shank1

Hung A, Futai K, Sala C, Valtschanoff J, Ryu J, Woodworth M et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience (2008)

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Altered sensitivities to morphine and cocaine in scaffold protein tamalin knockout mice

Ogawa M, Miyakawa T, Nakamura K, Kitano J, Furushima K, Kiyonari H et al.

Proceedings of the National Academy of Sciences of the United States of America (2007)

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M2 muscarinic acetylcholine receptor knock-out mice show deficits in behavioral flexibility, working memory, and hippocampal plasticity

Seeger T, Fedorova I, Zheng F, Miyakawa T, Koustova E, Gomeza J et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience (2004)

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Professional experience

Professor

Fujita Health University

April 2007 - Present

Education history

University of Tokyo

Ph. D.

March 1997 - Present