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Akash Bhattacharya

  • Mr
  • Postdoctoral Research Scientist
  • University of Texas Health Science Center at San Antonio
  • 8h-indexImpact measure calculated using publication and citation counts. Updated daily.
  • 271CitationsNumber of citations received by Akash's publications. Updated daily.

Research interests

ImmunologyHIVAnalytical UltracentrifugationProtein XRay crystallographyNMR SpectroscopyBiophysicsStructural Biology

About

CURRENT RESEARCH: The overarching theme of my research is to understand how the mammalian innate immune system responds to viral attack. The downstream application of this basic research will help in the development of better antiviral drugs. My current focus is on investigating how certain restriction factors such as TRIM5alpha, CPSF6 and SAMHD1 manage to reduce HIV infectivity – from the perspective of biochemistry/structural biology. This will lead to a better understanding of the pathways employed by HIV as it infects human cells, as well as casting new light on the molecules and mechanisms that the cell deploys to fight back against viral infection.

Co-authors (57)

Publications (5)

  • General model for retroviral capsid pattern recognition by TRIM5 proteins

    • Wagner J
    • Christensen D
    • Bhattacharya A
    • et al.
    N/AReaders
    0Citations
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  • The small-molecule 3G11 inhibits HIV-1 reverse transcription

    • Opp S
    • Fricke T
    • Shepard C
    • et al.
    N/AReaders
    0Citations
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  • Uncovering allostery and regulation in SAMHD1 through molecular dynamics simulations

    • Patra K
    • Bhattacharya A
    • Bhattacharya S
    N/AReaders
    1Citations
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  • Allosteric activation of SAMHD1 protein by deoxynucleotide triphosphate (dNTP)-dependent tetramerization requires dNTP concentrations that are similar to dNTP concentrations observed in cycling T cells

    • Wang Z
    • Bhattacharya A
    • Villacorta J
    • et al.
    N/AReaders
    4Citations
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  • Effects of T592 phosphomimetic mutations on tetramer stability and dNTPase activity of SAMHD1 can not explain the retroviral restriction defect

    • Bhattacharya A
    • Wang Z
    • White T
    • et al.
    N/AReaders
    N/ACitations
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Professional experience

Postdoctoral Research Scientist

Health Science Center - San Antonio - University of Texas Health Science Center at San Antonio

January 2012 - Present