CURRENT RESEARCH: The overarching theme of my research is to understand how the mammalian innate
immune system responds to viral attack. The downstream application of this basic research will help in the
development of better antiviral drugs.
My current focus is on investigating how certain restriction factors such as TRIM5alpha, CPSF6 and
SAMHD1 manage to reduce HIV infectivity – from the perspective of biochemistry/structural biology. This will
lead to a better understanding of the pathways employed by HIV as it infects human cells, as well as casting
new light on the molecules and mechanisms that the cell deploys to fight back against viral infection.
Allosteric activation of SAMHD1 protein by deoxynucleotide triphosphate (dNTP)-dependent tetramerization requires dNTP concentrations that are similar to dNTP concentrations observed in cycling T cells