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Aleksander M Grabiec

  • PhD
  • Marie Curie Fellow
  • Jagiellonian University Faculty of Biochemistry Biophysics and Biotechnology
  • 12h-indexImpact measure calculated using publication and citation counts. Updated daily.
  • 547CitationsNumber of citations received by Aleksander M's publications. Updated daily.

Research interests

rheumatologyregulation of transcriptionsignallingepigeneticsinnate immunityinflammation

About

Cell biologist with keen interest in epigenetic and transcriptional regulation in chronic inflammatory diseases. My research focuses on understanding how altered expression of epigenetic regulators, transcription factors and signalling molecules contributes to chronic inflammation, and on identification of novel therapeutic strategies targeting these alterations. I studied biotechnology at the Jagiellonian University in Cracow, Poland, and in 2007 I obtained my MSc degree with specialisation in biochemistry. I performed my doctoral research in the Department Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, The Netherlands, studying epigenetic and non-epigenetic contributions of histone deacetylases to inflammation in rheumatoid arthritis. In 2012 I received my PhD and then I continued my research on the interplay between epigenetics, transcription factor biology and signal transduction in synovial fibroblasts from patients with inflammatory rheumatic diseases as a postdoctoral researcher. From 2013 to 2016 I worked as a research associate at the Manchester Collaborative Centre for Inflammation Research (MCCIR), University of Manchester, UK, where I studied the contributions of defective apoptotic cell removal by airway macrophages to the pathology of acute and chronic lung inflammation. Since October 2016 I work as a Marie Skłodowska-Curie Fellow at the Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University in Cracow, Poland. I received a grant from the National Science Centre, Poland, within the POLONEZ 1 funding scheme, entitled: "Epigenetics of periodontitis: alterations in the host protein acetylation system as a potentially fundamental mechanism for disease development." This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 665778

Co-authors (87)

  • vanessa bensch
  • Ebrahim Mohammadi
  • Robert Ekiert
  • Gosia Trynka
  • Lukasz Kacprzyk

Publications (5)

  • Axl and MerTK receptor tyrosine kinases maintain human macrophage efferocytic capacity in the presence of viral triggers.

    • Grabiec A
    • Goenka A
    • Fife M
    • et al.
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  • Culture of Human Monocyte-Derived Macrophages.

    • Kelly A
    • Grabiec A
    • Travis M
    N/AReaders
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  • Epigenetic regulation in bacterial infections: targeting histone deacetylases.

    • Grabiec A
    • Potempa J
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  • TIMP-1 association with collagen type I overproduction in hereditary gingival fibromatosis.

    • Gawron K
    • Ochała-Kłos A
    • Nowakowska Z
    • et al.
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  • Endoplasmic reticulum stress cooperates with Toll-like receptor ligation in driving activation of rheumatoid arthritis fibroblast-like synoviocytes.

    • Kabala P
    • Angiolilli C
    • Yeremenko N
    • et al.
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Editorships

Seminars in Immunopathology

Guest Editor - special issue "Immunopathology of Lung Diseases"; Volume 38, Issue 4, July 2016

2016

Professional experience

Marie Curie Fellow

Uniwersytet Jagiellonski Wydzial Biochemii Biofizyki i Biotechnologii

October 2016 - Present

Postdoctoral Research Associate

MCCIR, University of Manchester

August 2013 - September 2016(3 years)

Postdoctoral researcher

Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam

August 2012 - July 2013(a year)

PhD student

Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam

October 2007 - June 2012(5 years)

Practical laboratory training

Department of Cell Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland

September 2004 - June 2006(2 years)

Education

PhD in biomedical sciences (dissertation: http://dare.uva.nl/record/420882)

Academic Medical Center, University of Amsterdam

September 2007 - June 2012(5 years)

MSc in biotechnology, major in biochemistry

Jagiellonian University

October 2002 - June 2007(5 years)