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Alessandro Palmioli

  • PhD
  • 4PublicationsNumber of items in Alessandro's My Publications folder on Mendeley.
  • 1Followers

Research interests

Bioconjugate Chemistry.Bioorganic ChemistryOrganic Synthesis

About

Obtained MSc in Industrial Biotechnology in February 2005, he starts a collaboration with Diasorin SpA, an industrial group that operates in vitro diagnostic branch, working in the Dept. of Biotecnology and Biosciences, University of Milano-Bicocca, in the Prof. Francesco Nicotra Research Group under the supervision of Prof. Francesco Peri. His work concerns on synthesis of chemiluminescent and immunoreagents in order to develop new probes useful for Chemiluminescent Immuno Assay (CLIA) technologies. In 2006 he starts his PhD in Chemistry in Prof. Francesco Peri Research Group, working on organic/medicinal chemistry. His work concerns on synthesis of new potential inhibitors of Ras protein based on glycidic scaffold as potential antitumor agents. During this period he had also different experiences as didactics tutor in Organic Chemistry, in General and Inorganic Chemistry and in Laboratory courses. In December 2009, he obtains the PhD in Chemistry and now he is continuing his collaboration with Diasorin SpA as external advisor in a tight collaboration with R&D and the Production division. Since April 2010 he has a full-time temporary position in the Nerviano Research Centre (Diasorin SpA) as organic chemistry researcher in the immunochemistry unit. TECHNICAL SKILLS Organic Chemist skilled in planning and execute multi-step synthesis, purification (flash chromatography, preparative HPLC, extraction and crystallization) and analytical characterization (NMR, Mass spectrometry, TLC). Experienced in evaluating structure-activity relationship and design optimization of putative bioactive compounds (rational drug design). Experienced in working with a multidisciplinary scientific group.

Followers (1)

Publications (4)

  • Structure-Activity Studies on Arylamides and Arysulfonamides Ras Inhibitors

    • Colombo S
    • Palmioli A
    • Airoldi C
    • et al.
    N/AReaders
    N/ACitations
  • First experimental identification of Ras-inhibitor binding interface using a water-soluble Ras ligand.

    • Palmioli A
    • Sacco E
    • Abraham S
    • et al.
    N/AReaders
    N/ACitations
    Get full text
  • Selective cytotoxicity of a bicyclic Ras inhibitor in cancer cells expressing K-Ras(G13D).

    • Palmioli A
    • Sacco E
    • Airoldi C
    • et al.
    N/AReaders
    N/ACitations
    Get full text
  • Glucose-derived Ras pathway inhibitors: evidence of Ras-ligand binding and Ras-GEF (Cdc25) interaction inhibition.

    • Airoldi C
    • Palmioli A
    • D'Urzo A
    • et al.
    N/AReaders
    N/ACitations
    Get full text

Professional experience

Researcher (full-time temporary position)

Diasorin SpA

April 2010 - March 2011(a year)

Project Collaboration

Diasorin SpA

July 2009 - March 2010(8 months)

Scientific Collaboration

Diasorin SpA

April 2008 - April 2009(a year)

Research Grant

Dept. of Biotechnology and Biosciences, University of Milano Bicocca

August 2006 - July 2007(a year)

Research Grant

Dept. of Biotechnology and Biosciences, University of Milano Bicocca

August 2005 - July 2006(a year)

Scientific collaboration

Diasorin SpA

February 2005 - August 2005(6 months)

Education

PhD in Chemistry

Dept. of Biotechnology and Biosciences, University of Milano Bicocca

November 2006 - November 2009(3 years)

Specialization Course “Industrial Processes and Management in Pharmaceutical and Fine Chemistry”

Università degli Studi di Milano

December 2005 - December 2006(a year)

MSc in industrial Biotechnology

Dept. of Biotechnology and Biosciences, University of Milano Bicocca

October 1999 - February 2005(5 years)

High school degree in Industrial Chemistry

Industrial Technical Institute E. Molinari, Milano

September 1994 - June 1999(5 years)