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Alfonso Soler Bistué

  • PhD
  • EMBO Fellow
  • Institute Pasteur
  • 16PublicationsNumber of items in Alfonso's My Publications folder on Mendeley.
  • 21Followers

Research interests

antibioticsVibrio choleraeGenome biologyHGT

About

Curriculum Vitae Alfonso J.C. Soler Bistué, MsC alfsoler@gmail.com Education: August 2005 to present: Doctoral Fellow of the Biochemistry and Genetics of Rhizobacteria Laboratory directed by Dr. Angeles Zorreguieta at the Leloir Institute. Thesis to be defended December 2010 July 2005 M.Sc., Biology, Universidad de Buenos Aires, Argentina Teaching Experience: 04/01/08 to present: Teaching assistant (1st class), Department of Biological Chemistry, Faculty of Exact and Natural Sciences, University of Buenos Aires. Courses: General Microbiology and Inmunology, Bacterial Genetics 08/22/03 to 02/28/07: Teaching assistant (2nd class), Faculty of Exact and Natural Sciences, University of Buenos Aires. Courses: General and Industrial Microbiology, Bacterial Genetics, General Ecology, Biochemistry and Molecular Biology Techniques, Biological Chemistry II-A “Cell Biology”, Biological Chemistry II-B ”Protein Chemistry” Research Experience: 03/01/2007 to 05/27/2007 ASM International Fellows at California State University Fullerton, CA, USA. Subject: Use Oligodeoxynucleotides analogs for aac(6’)-Ib silencing in vitro by antisense technology. Advisor: Marcelo E. Tolmasky 2005 to present Thesis work. “Silencing the gene responsible for amikacin resistance aac(6')-Ib using antisense technology: desing of oligomers for RNAse P based strategies” Advisors: Angeles Zorreguieta, Ph.D., Leloir Institute, Buenos Aires, Argentina and Marcelo E. Tolmasky Ph.D. Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton, Fullerton, CA, USA. 2004-2005: MSc Thesis work: Subject: “An unusual type 1 integron responsible for amikacin resistance in Vibrio cholerae”. Advisors: Angeles Zorreguieta, Ph.D., Leloir Institute, Buenos Aires, Argentina and Marcelo E. Tolmasky Ph.D. Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton, Fullerton, CA, USA. 2001-2003 Laboratory work as undergraduate student. Subject: Tissue specific regulation of apoptosis by sexual Steroids. Advisors: Adalí Pecci, Ph.D., José Lino Barañao Ph. D. Department of Biological Chemistry-Faculty of Natural and Exact Sciences, University of Buenos Aires Training Experience: • February 2009 to present: Assistant Supervisor of Carol G. Davies, M.Sc. student of the University of Buenos Aires. • June to August 2008: Training of Doreen E. Carpio, MHIRT (Minority Health and Health Disparities Training Program, NIH) scholar from California State University, Fullerton. • June to August 2007: Training of Jonathan Joaquín, MHIRT (Minority Health and Health Disparities Training Program, NIH) scholar from California State University, Pomona. • June to August 2006: Training of Michelle Don, MHIRT (Minority Health and Health Disparities Training Program, NIH) scholar from California State University, Fullerton. Awards: Graduate Student Scholarships Awarded: April 2009 to present: Doctoral Scholarship “Beca Doctoral Tipo II” from CONICET (National Council of Scientific and Technical Investigations, Argentina) March to May 2007: ASM International Fellowship for Latin America from the American Society for Microbiology (ASM). March 2006 to March 2009: Doctoral Scholarship “Beca Doctoral Tipo I” from CONICET (National Council of Scientific and Technical Investigations, Argentina) August 2005 to March 2006: Doctoral Scholarship from “Fundación Ciencias Exactas y Naturales” Undergraduate Student Scholarships Awarded: April 2002 to April 2003: Undergraduate Scholarship for research Initiation. University of Buenos Aires, Buenos Aires, Argentina Supervisor: José Lino Barañao. Publications: • Peer-reviewed Journals: 1- Ramirez MS, Don M, Merkier AK, Soler Bistué AJ, Zorreguieta A, Centrón D, Tolmasky ME. A naturally competent Acinetobacter baumannii clinical isolate as a convenient model for genetic studies. J Clin Microbiol. Apr;48(4):1488-90 2- Soler Bistué AJ, Martín FA, Vozza N, Ha H, Joaquín JC, Zorreguieta A, Tolmasky ME. Inhibition of aac(6')-Ib-mediated amikacin resistance by nuclease-resistant external guide sequences in bacteria. Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13230-5. 3- Soler Bistué AJ, Birshan D, Tomaras AP, Dandekar M, Tran T, Newmark J, Bui D, Gupta N, Hernandez K, Sarno R, Zorreguieta A, Actis LA, and Tolmasky ME. Klebsiella pneumoniae multiresistance plasmid pMET1: similarity with the Yersinia pestis plasmid pCRY and integrative conjugative elements. PLoS ONE 2008 Mar 19;3(3):e1800 4-Quiroga MP, Andres P, Petroni A, Soler Bistué AJ, Guerriero L, Vargas LJ, Zorreguieta A, Tokumoto M, Quiroga C, Tolmasky ME, Galas M, Centrón D. Complex class 1 integrons with diverse variable regions, including aac(6')-Ib-cr, and a novel allele, qnrB10, associated with ISCR1 in clinical enterobacterial isolates from Argentina. Antimicrob Agents Chemother. 2007 Dec;51(12):4466-70. 5- Soler Bistue AJ, Ha H, Sarno R, Don M, Zorreguieta A, Tolmasky ME. External guide sequences targeting the aac(6')-Ib mRNA induce inhibition of amikacin resistance. Antimicrob Agents Chemother. 2007 Jun;51(6):1918-25. 6- Soler Bistue AJ, Martin F, Petroni A, Faccone D, Galas M, Tolmasky ME, Zorreguieta A. Vibrio cholerae InV117, a class 1 integron harboring aac(6')-Ib and blaCTX-M-2, is linked to transposition genes. Antimicrob Agents Chemother. 2006 May;50(5):1903-7. • Thesis 2005: Thesis to achieve the “Licenciatura en Ciencias Biológicas” from the University of Buenos Aires (Equivalent to MSc):Supervisor: Ángeles Zorreguieta. Cosupervisor: Marcelo Tolmasky. Title: “An unusual type 1 integron responsible for amikacin resistance in Vibrio cholerae” .Grade: 10/10 2010 In preparation: PhD Thesis from the University of Buenos Aires: Supervisor: Ángeles Zorreguieta. Cosupervisor: Marcelo Tolmasky. Title: “Antisense technology against multiresistant bacteria”. • Conference proceedings: Internacional meetings: 2010: 110th American Society for Microbiology (ASM) General Meeting at San Diego, California, USA “Optimization of LNA/DNA co-oligomers as EGS inducers of mRNA degradation by RNase P: an alternative strategy to deal with antibiotic resistance”. Soler Bistué A.J.C., Davies Sala C.G., Carpio DE, Angeles Zorreguieta and Marcelo E. Tolmasky. 2009: 109th American Society for Microbiology (ASM) General Meeting at Philadelphia, Pensylvania, USA “Locked Nucleic Acid-containing External Guided Sequences Induce Amikacin Suceptibility on Escherechia coli Harboring aac(6’)-Ib”. Soler Bistué A.J.C., Martín FA, Ha H, Joaquín JC, Carpio DE, Angeles Zorreguieta and Marcelo E. Tolmasky. 2009:49th Conference on Antimicrobial Agents and Chemotherapy (ICAAC) at San Francisco, USA, “Plasmid Mediated Quinolone Resistance Mechanisms (PMQRs) in Clinical Enterobacteria from Argentina: A View from the Microbiological Practice” Andrés P, Soler Bistué A., Guerriero L. , Lucero C, Ceriana P, Zorreguieta A, Corso A, Petroni A 2007: 47th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) at Chicago, USA, “Transferable Quinolone Resistance (TQR) in Enterobacteria from Argentina: aac(6’)-Ib-cr and a Novel qnrB Allele (qnrB6) are Located in a Complex Class 1 Integron”, Petroni A., Andrés P., Soler Bistué A.J.C., Quiroga P., Zorreguieta A., Centrón D., Galas M. 2007: 107th American Society for Microbiology (ASM) General Meeting at Toronto, Canadá “Antisense External Guided Sequences Targeting aac(6')-Ib Reverse Amikacin Resistance”, Soler Bistué AJC, Ha H, Sarno R, Don M, Zorreguieta A, and Tolmasky ME 2005: 45th ICAAC™ Meeting Washington DC. Poster presentation: “Vibrio cholerae multiple resistance is encoded by a transposonlike structure including a class 1 integron that harbors aac(6´)I-b and blaCTX-M-2.”, A Soler Bistué, F Martin, D Faccone, A Petroni, M Galas, A Zorreguieta, M E Tolmasky Awarded with “ASM Student and Post Doctoral Fellow Travel Grant” 2004: XVII Latinoamerican Congress of Microbiology Buenos Aires, Argentina. Poster presentation “Identificación de aac(6´)-Ib dentro de un integrón en aislamientos de Vibrio Cholerae en Argentina” Soler Bistué A. J. C. , Martín F., Faccone D, Petroni A, Galas M, Zorreguieta A y Tolmasky M. National meetings: 2009: Annual meeting of the National Society of General Microbiology (SAMIGE) at Villa Carlos Paz, Cordoba, Argentina. Poster presentation: “Improvements in the design of non-hydrolyzable LNA/DNA antisense oligonucleotides that interfere with amikacin resistance in vivo” Carol G. Davies Sala, Alfonso J. Soler Bistué , Fernando A. Martín, Nicolás F. Vozza, Doreen E. Carpio, Angeles Zorreguieta, Marcelo E. Tolmasky 2008: Annual meeting of the National Society of General Microbiology (SAMIGE) at Rosario, Santa Fe, Argentina. Oral presentation: “Non-hydrolyzable antisense oligonucleotides direct aac(6’)-Ib mRNA cleavage by RNAse P.” Alfonso J.C. Soler Bistué, Hongphuc Ha, Angeles Zorreguieta and Marcelo E. Tolmasky 2007: Annual meeting of the Argentinean Society for Research in Biochemistry and Molecular Biology (SAIB) at Mar del Plata. Poster presentation: “Inhibition of amikacin resistance using an RNAse P based strategy to silence aac(6’)-Ib” Alfonso J.C. Soler Bistué, Hongphuc Ha, Angeles Zorreguieta, Marcelo E. Tolmasky 2006: Annual meeting of the Argentinean Society for Research in Biochemistry and Molecular Biology (SAIB) at Rosario, Santa Fe, Argentina. Poster presentation: “Suppression of amikacin resistance due to aac(6’)-Ib by RNase P-based antisense technology.” Alfonso J.C. Soler Bistué, Hongphuc Ha, Angeles Zorreguieta, Marcelo E. Tolmasky Courses Attended 1st Regional School of Microbiology. AMSUD-PASTEUR Institute of Biological Investigations “Clemente Estable”, Montevideo, Uruguay. 10/05/09-10/17/09 BioStatistics, Institute of Biology and Experimental Medicine (IByME). 08/31/2009-09/04/2009 Proteomic Approaches in Molecular Biology: Theory and Practice. INTERNATIONAL CENTRE FOR GENETIC ENGENEERING AND BIOTECHNOLOGY (ICGEB) Department of Biological Chemistry -FCEN-UBA, Buenos Aires, Argentina. 03/03/08 - 03/14/08 Molecular Techniques and Statistics to study Genomic Diversity and Proteomics in Microbial Communities. CABBIO State University of Campinas, Multidisciplinary Biological and Agricultural Research Center, Microbial Resources Division, Brazil. 06/16/08 - 06/27/08 Molecular Genetics of Yeasts. Department of Physiology and Molecular and Cellular Biology, FCEN, UBA and Leloir Institute. Buenos Aires, Argentina. 09/15/08 - 10/07/08 Biology of RNA. Department of Biological Chemistry-FCEN-UBA y Leloir Institute. Buenos Aires, Argentina. Special guest: Sidney Altman, Nobel Prize 1989. 08/07/07 - 08/24/07 Molecular and Cell Microbiology. Department of Biological Chemistry -FCEN-UBA y Leloir Institute. Buenos Aires, Argentina. 06/11/07 - 07/02/07 XX Intensive Course on Antimicrobial Agents “Dra. Alicia Rossi”. Antimicrobial Service of the National Institute of Infectious Diseases, ANLIS "Dr. Carlos G. Malbrán". Buenos Aires, Argentina. 04/24/06 - 05/05/06 Memberships • National Society of General Microbiology (SAMIGE), since 2006 • American Society for Microbiology, since 2005 • Argentinean Society for Research in Biochemistry and Molecular Biology (SAIB-IUBMB), since 2002 Language Skills • Spanish: Native • English: Speak, write and read fluently. • French: Speak, write and read fluently

Followers (21)

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Publications (5)

  • External guide sequence technology: A path to development of novel antimicrobial therapeutics

    • Davies-Sala C
    • Soler-Bistué A
    • Bonomo R
    • et al.
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  • Genomic Location of the Major Ribosomal Protein Gene Locus Determines Vibrio cholerae Global Growth and Infectivity

    • Soler-Bistué A
    • Mondotte J
    • Bland M
    • et al.
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  • Fuse or die: how to survive the loss of Dam in Vibrio cholerae.

    • Val M
    • Kennedy S
    • Soler-Bistué A
    • et al.
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  • Management of multipartite genomes: The Vibrio cholerae model

    • Val M
    • Soler-Bistu?? A
    • Bland M
    • et al.
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  • Differential Distribution of Plasmid Mediated Quinolone Resistance Genes in Clinical Enterobacteria with Unusual Phenotypes of Quinolone Susceptibility from Argentina.

    • Andres P
    • Lucero C
    • Soler-Bistué A
    • et al.
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Professional experience

EMBO Fellow

Institut Pasteur

May 2011 - Present

PhD student

Fundacion Instituto Leloir/Dpto Quimica Biologica, FCEN, UBA

August 2005 - April 2011(6 years)

Education

PhD

Fundacion Instituto Leloir/Dpto Quimica Biologica, FCEN, UBA

August 2005 - December 2010(5 years)

Lic.

Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires

August 2004 - July 2005(a year)