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Amit V Pandey

  • PD Dr
  • Principal Investigator
  • University Children's Hospital Bern, CH
  • 22h-indexImpact measure calculated using publication and citation counts. Updated daily.
  • 2413CitationsNumber of citations received by Amit V's publications. Updated daily.

Other IDs

Research interests

Computational biology and bioinformaticsHuman Growth hormoneGenetics and Molecular Biology of sex steroid biosynthesis. Metabolic disorders. Cytochrome P450 proteins P450 reductase

About

Amit Pandey (http://www.pandeylab.org/index.html ) studied physics as an undergraduate student at Canning College, University of Lucknow and later shifted to biochemistry for graduate studies, specialising in heme metabolism in malaria parasite at the department of biochemistry, Central Drug Research Institute Lucknow, India. Dr. Pandey continued to work on heme binding and metabolism by malaria proteins at The International Centre for Genetic Engineering and Biotechnology in New Delhi, India working with Prof. Virander S Chauhan he described the mechanism of action of antimalarial drugs artemisinin and chloroquine. http://www.jbc.org/content/274/27/19383.long http://www.biochemj.org/content/355/2/333.long In 2000 Dr. Pandey joined the laboratory of Prof. Walter L Miller at the University of California San Francisco, where he studied the molecular biology of steroid metabolizing cytochrome P450 enzymes. Working in Miller lab Dr. Pandey described the roles of cytochrome b5 and phosphorylation in regulation of 17,20 lyase activities of CYP17A1. http://www.jbc.org/content/278/5/2837.long http://www.jbc.org/content/280/14/13265.long In 2004, together with Drs. Christa Flück and Walter L Miller in San Francisco and Fujieda and Tajima in Japan, Dr. Pandey published (Nature Genetics, March 2004) the reports on first mutations in POR (NADPH P450 oxidoreductase). http://www.nature.com/ng/journal/v36/n3/full/ng1300.html In 2005 together with Dr. Ningwu Huang Dr. Pandey published the largest study of mutations and polymorphisms in human POR gene (American J Hum Genetics 2005). http://www.sciencedirect.com/science/article/pii/S0002929707607216 In 2005 Dr. Pandey moved to University of Bern Switzerland and received funding from the Swiss National Science Foundation for studying the Pharmacogenomics of P450 oxidoreductase. In 2007 Dr. Pandey described the differences in activities of POR mutants between CYP17A1 and CYP19A1 (aromatase). In 2010 Dr. Pandey published first reports of POR variants affecting the activities of CYP3A4 and heme oxygenase. http://www.sciencedirect.com/science/article/pii/S0006291X10017171 http://www.sciencedirect.com/science/article/pii/S0006291X10015676 In 2010 Dr. Pandey completed his habilitation in Endocrinology at University of Bern and became Privatdozent at the Medical Faculty of the University of Bern. In 2011 together with Drs. Christa E Flück, Anna Biason-Lauber and Walter L Miller, Dr. Pandey published the first report of mutations in AKR1C2 and AKR1C4 affecting male sexual development (Am J Hum Genetics 2011). http://www.sciencedirect.com/science/article/pii/S000292971100262X MANUSCRIPT REVIEWER FOR FOLLOWING JOURNALS Biochemical Journal, Scientific Reports, PLOS One, Xenobiotica, European Journal of Endocrinology, Mol. Cell. Endocrinol., Reproductive Endocrinology, Endocrine; Journal of Steroid Biochemistry and Molecular Biology, Drug Metabolism and disposition, Drug Metabolism & Pharmacokinetics, Pharmacogenetics & Genomics, Pharmacogenomics, Frontiers in Pharmacology Journal of Inorganic Biochemistry, , Chemical Physics Letters, J Biol Sci, Process Biochemistry, Member Editorial Board: Advances in Life Sciences Associate Editor: Frontiers in Pharmacology Awards: Young Investigator Award for 2007 by Swiss Society for Endocrinology & Diabetology. Servier Research Prize in Endocrinology (2008) Grants: Swiss National Science Foundation: Since 2007- on Characterization of P450 reductase deficiency. Roche Foundation, Novartis Foundation for Medicine and Biology Research, Servier Swiss Society for Endocrinology and Diabetology, Bern University Research Foundation

Co-authors (192)

  • Mostafa Al-Sharkawi
  • ika danjuma mbateudi
  • faizal hermanto
  • Praveen Awasthi
  • Mahboob Imtiyaz

Publications (5)

  • GATA4 variants in individuals with a 46,XY Disorder of Sex Development (DSD) may or may not be associated with cardiac defects depending on second hits in other DSD genes

    • de LaPiscina I
    • de Mingo C
    • Riedl S
    • et al.
    N/AReaders
    0Citations
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  • Mechanism of the dual activities of human CYP17A1 and binding to anti-prostate cancer drug abiraterone revealed by a novel V366M mutation causing 17,20 lyase deficiency

    • Fernández-Cancio M
    • Camats N
    • Flück C
    • et al.
    N/AReaders
    0Citations
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  • Editorial: Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function

    • Pandey A
    • Henderson C
    • Ishii Y
    • et al.
    N/AReaders
    N/ACitations
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  • Genes and proteins of the alternative steroid backdoor pathway for dihydrotestosterone synthesis are expressed in the human ovary and seem enhanced in the polycystic ovary syndrome

    • Marti N
    • Galván J
    • Pandey A
    • et al.
    N/AReaders
    8Citations
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  • Endoplasmic reticulum stress enhances mitochondrial metabolic activity in mammalian adrenals and gonads

    • Prasad M
    • Walker A
    • Kaur J
    • et al.
    N/AReaders
    4Citations
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Editorships

Frontiers in Pharmacology

Associate Editor

2013 - Present

Professional experience

Principal Investigator

University Children's Hospital Bern, CH

July 2007 - Present

Research Scientist

Universität Bern - University of Bern

September 2005 - Present

Education

PhD

RML Avadh University

December 1993 - December 1999(6 years)

MSc

Lucknow University

August 1990 - August 1992(2 years)

BSc

Lucknow University

August 1987 - July 1990(3 years)