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Andrei Gudkov

  • Senior Vice President for Basic Research and Chair of the Department of Cell Stress Biology
  • Roswell Park Cancer Institute
  • 28PublicationsNumber of items in Andrei's My Publications folder on Mendeley.

Research interests

Cellular foundations of agingMolecular targets for cancer treatmentGene discoveryDrug discovery approaches

About

Dr. Gudkov has over 30 years of experience in biomedical research. He is the Founder and Chief Scientific Officer of Everon Biosciences, Inc. At the moment Everon Biosciences is optimizing several lead compounds, both small molecules and biologics that have already demonstrated a rejuvenation effect in aging animals, as measured by a lowered mouse Frailty Index (FI). This FI is an indicator of how far away physiological measurements of an aging mouse deviated from those in average young mice. Similar FI has recently been accepted by FDA as a measure of aging in a currently running Metformin human trial. In preliminary experiments, rejuvenated animals live on average 25-30% longer, and this number is expected to increase as optimization continues. Aside from his work at Everon, Dr. Gudkov has served as Principal Investigator on a series of NIH-funded programs. He has authored or co-authored 135 research papers and, as an inventor, holds 27 issued U.S. patents in the cancer area.

Publications (5)

  • CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements

    • Somers K
    • Gudkov A
    • Chudakova D
    • et al.
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  • Distinguishing the immunostimulatory properties of noncoding RNAs expressed in cancer cells

    • Tanne A
    • Muniz L
    • Puzio-Kuter A
    • et al.
    N/AReaders
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  • INTRODUCTION

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  • Powerful complex immunoadjuvant based on synergistic effect of combined TLR4 and NOD2 activation significantly enhances magnitude of humoral and cellular adaptive immune responses

    • Tukhvatulin A
    • Dzharullaeva A
    • Gudkov A
    • et al.
    N/AReaders
    N/ACitations
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  • p53 determines multidrug sensitivity of childhood neuroblastoma

    • Xue C
    • Haber M
    • Gudkov A
    • et al.
    N/AReaders
    N/ACitations
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Professional experience

Senior Vice President for Basic Research and Chair of the Department of Cell Stress Biology

Roswell Park Cancer Institute

January 2007 - Present

Chairman of the Department of Molecular Biology

Lerner Research Institute

January 2001 - January 2007(6 years)