and the neuroimmune factors that influence depression. Models include aged mice and transgenic mice.microgliaNeuroinflammation
Angela is a Ph.D. candidate in the neuroscience graduate studies program at the Ohio State University. She is working in the laboratory of Dr. Jonathan Godbout. Current research interests include the regulation of microglial cells, fractalkine to fractalkine receptor interactions, and the effects of neuroinflammation on depression. She plans on finishing her Ph.D. thesis on the above topics by Summer of 2011.
Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1beta and anti-inflammatory IL-10 cytokines.