Dr Lorenzini focus is on the cellular mechanisms that ensure longevity and on the extracellular and intracellular signaling that regulate them. In the laboratory of Dr Vincent Cristofalo he has focused on intercellular signaling regulating cell proliferation and senescence and on the differential proliferative capacity of mammals and how this correlate with life span. With Dr Christian Sell at Drexel University, he has investigated the endocrine modulation of longevity trying to separate the influence of GH from that of IGF-1. Now he operate in Department of Biomedical and Neuromotor Sciences of the University of Bologna where his main research focus is the understanding of how DNA damage signaling interact with cell cycle progression. For this aim he is exploiting the comparative approach using a cell bank of mammals with different longevity.