Brian Bot

  • Senior Scientist
  • Sage Bionetworks
14

Publications

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Readers

Research Interests

challenging the scientific status quo

Followers (10)

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Following (9)

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About

I am currently a Senior Scientist at Sage Bionetworks working with large genetic, genomic and phenotypic datasets. This role requires advanced knowledge of a wide variety of subject matters including computational biology, biostatistics, bioinformatics, and a number of biological endpoints. Endpoints of particular interest are genetic mutations (SNP, CNV, etc.), RNA expression (miRNA, exon, gene-level), and protein production. Methods to integrate these endpoints are of particular interest and importance. We are currently working to create standardized open-source data structures and formats which will aid in increasing the accessibility and ease of analysis of biological data.

In providing open access to a large number of integrated datasets, we hope to stimulate the discovery and validation of biological networks that will help to explain disease specific etiology.

Publications

Developing predictive molecular maps of human disease through community-based modeling

Derry J, Mangravite L, Suver C, Furia M, Henderson D, Schildwachter X, Bot B, Izant J, Sieberts S, Kellen M, Friend S

Nature Genetics (2012)

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Technical and biological variance structure in mRNA-Seq data: life in the real world.

Oberg A, Bot B, Grill D, Poland G, Therneau T

BMC genomics (2012)

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Comparative assessment of trial-level surrogacy measures for candidate time-to-event surrogate endpoints in clinical trials

Shi Q, Renfro L, Bot B, Burzykowski T, Buyse M, Sargent D

Computational Statistics & Data Analysis (2011)

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Evaluation of Guanylyl Cyclase C Lymph Node Status for Colon Cancer Staging and Prognosis.

Sargent D, Resnick M, Meyers M, Goldar-Najafi A, Clancy T, Gill S, Siemons G, Shi Q, Bot B, Wu T, Beaudry G, Haince J, Fradet Y

Annals of surgical oncology (2011)

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Expression of endothelin 2 and localized clear cell renal cell carcinoma.

Bot B, Eckel-Passow J, Legrand S, Hilton T, Cheville J, Igel T, Parker A

Human pathology (2011)

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Professional experience

Senior Scientist

Sage Bionetworks

December 2011 - Present

QC Statistical Geneticist

Sage Bionetworks

June 2011 - December 2011 (6 months)

Senior Statistical Analyst

Mayo Clinic Cancer Center Department of Molecular Pharmacology and Experimental Therapeutics

July 2008 - June 2011 (2 years 11 months)

Statistical Analyst II

Mayo Clinic Cancer Center Department of Molecular Pharmacology and Experimental Therapeutics

August 2006 - June 2008 (1 year 10 months)

Statistical Analyst

Mayo Clinic Cancer Center Department of Molecular Pharmacology and Experimental Therapeutics

May 2004 - August 2006 (2 years 3 months)

Education history

University of Minnesota Twin Cities

Statistics

September 2000 - December 2003 (3 years 3 months)