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Brian Bot

  • Senior Scientist
  • Sage Bionetworks
  • 0ReadersNumber of instances of Brian's publications in Mendeley libraries. Updated daily.
  • 5PublicationsNumber of items in this person’s My Publications folder on Mendeley.

Research interests

challenging the scientific status quo

About

I am currently a Senior Scientist at Sage Bionetworks working with large genetic, genomic and phenotypic datasets. This role requires advanced knowledge of a wide variety of subject matters including computational biology, biostatistics, bioinformatics, and a number of biological endpoints. Endpoints of particular interest are genetic mutations (SNP, CNV, etc.), RNA expression (miRNA, exon, gene-level), and protein production. Methods to integrate these endpoints are of particular interest and importance. We are currently working to create standardized open-source data structures and formats which will aid in increasing the accessibility and ease of analysis of biological data. In providing open access to a large number of integrated datasets, we hope to stimulate the discovery and validation of biological networks that will help to explain disease specific etiology.

Followers (10)

Explore network

Following (9)

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Publications

Developing predictive molecular maps of human disease through community-based modeling

  • Derry J
  • Mangravite L
  • Suver C
Nature Genetics (2012)
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Technical and biological variance structure in mRNA-Seq data: life in the real world.

  • Oberg A
  • Bot B
  • Grill D
BMC genomics (2012)
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Comparative assessment of trial-level surrogacy measures for candidate time-to-event surrogate endpoints in clinical trials

  • Shi Q
  • Renfro L
  • Bot B
Computational Statistics & Data Analysis (2011)
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Expression of endothelin 2 and localized clear cell renal cell carcinoma.

  • Bot B
  • Eckel-Passow J
  • Legrand S
Human pathology (2011)
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Integrated analysis of gene expression, CpG island methylation, and gene copy number in breast cancer cells by deep sequencing.

  • Sun Z
  • Asmann Y
  • Kalari K
PloS one (2011)
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Professional experience

Senior Scientist

Sage Bionetworks

December 2011 - Present

QC Statistical Geneticist

Sage Bionetworks

June 2011 - December 2011(6 months)

Senior Statistical Analyst

Mayo Clinic

July 2008 - June 2011(3 years)

Statistical Analyst II

Mayo Clinic

August 2006 - June 2008(2 years)

Statistical Analyst

Mayo Clinic

May 2004 - August 2006(2 years)

Education history

Statistics

University of Minnesota - Twin Cities

September 2000 - December 2003(3 years)